STAG2

STAG2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PJU, 4PJW, 4PK7
Identifiers
Aliases	STAG2, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13
External IDs	OMIM: 300826 MGI: 1098583 HomoloGene: 38206 GeneCards: STAG2
Gene location (Human)
Chr.	X chromosome (human)
End	124,422,664 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	41,366,062 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; spongy bone; ; lower lobe of lung; ; lactiferous duct; ; germinal epithelium; ; caput epididymis; ; corpus epididymis; ; superficial temporal artery; ; retinal pigment epithelium;
	Top expressed in
	left lung lobe; ; parotid gland; ; atrioventricular valve; ; carotid body; ; medial ganglionic eminence; ; lacrimal gland; ; hair follicle; ; molar; ; iris; ; renal corpuscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; chromatin binding;
Cellular component	cytosol; membrane; chromosome; nucleoplasm; chromatin; chromosome, centromeric region; nucleus; cohesin complex; nuclear matrix; mitotic spindle pole;
Biological process	chromosome segregation; cell division; negative regulation of DNA endoreduplication; meiosis; cell cycle; sister chromatid cohesion; regulation of mitotic spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	10735
	20843
	ENSG00000101972
	ENSMUSG00000025862
	Q8N3U4
	O35638
NM_001042749; NM_001042750; NM_001042751; NM_001282418; NM_006603;
	NM_001375375
	NM_001077712; NM_001290713; NM_021465; NM_001358225
NP_001036214; NP_001036215; NP_001036216; NP_001269347; NP_006594;
	NP_001362304
	NP_001071180; NP_001277642; NP_067440; NP_001345154
	Wikidata
View/Edit Human	View/Edit Mouse

Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

STAG2 is frequently mutated in a range of cancers and several other disorders.

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