SMC1A

Structural maintenance of chromosomes protein 1A (SMC1A) is a protein that in humans is encoded by the SMC1A gene. SMC1A is a subunit of the cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

SMC1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, structural maintenance of chromosomes 1A, EIEE85, DEE85
External IDsOMIM: 300040 MGI: 1344345 HomoloGene: 4597 GeneCards: SMC1A
Orthologs
SpeciesHumanMouse
Entrez

8243

24061

Ensembl

ENSG00000072501

ENSMUSG00000041133

UniProt

Q14683
Q68EN4

Q9CU62

RefSeq (mRNA)

NM_006306
NM_001281463

NM_019710

RefSeq (protein)

NP_001268392
NP_006297
NP_006297.2

NP_062684

Location (UCSC)Chr X: 53.37 – 53.42 MbChr X: 150.8 – 150.85 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

SMC1A is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation from bacteria to humans.

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