SMC1B

SMC1B
Identifiers
Aliases	SMC1B, SMC1BETA, SMC1L2, structural maintenance of chromosomes 1B
External IDs	OMIM: 608685 MGI: 2154049 HomoloGene: 13786 GeneCards: SMC1B
Gene location (Human)
Chr.	Chromosome 22 (human)
End	45,413,619 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	85,016,165 bp
RNA expression pattern
	Top expressed in
	monocyte; ; Achilles tendon; ; lymph node; ; thymus; ; appendix; ; gallbladder; ; blood; ; placenta; ; smooth muscle tissue; ; gastrocnemius muscle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; secondary oocyte; ; morula; ; ovary; ; blastocyst; ; liver; ; spleen; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; ATP binding;
Cellular component	lateral element; condensed nuclear chromosome; synaptonemal complex; chromosome, centromeric region; nucleus; nucleoplasm; chromosome; meiotic cohesin complex; cytosol;
Biological process	cell cycle; meiosis; chromosome organization; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	27127
	140557
	ENSG00000077935
	ENSMUSG00000022432
	Q8NDV3
	Q920F6
	NM_001291501; NM_148674
	NM_080470
	NP_001278430; NP_683515
	NP_536718
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 1B (SMC-1B) is a protein that in humans is encoded by the SMC1B gene. SMC proteins engage in chromosome organization and can be broken into 3 groups based on function which are cohesins, condensins, and DNA repair. SMC-1B belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis. SMC1B protein appears to participate with other cohesins REC8, STAG3 and SMC3 in sister-chromatid cohesion throughout the whole meiotic process in human oocytes.

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