STAG1

STAG1
Identifiers
Aliases	STAG1, SA1, SCC3A, stromal antigen 1, MRD47
External IDs	OMIM: 604358 MGI: 1098658 HomoloGene: 21191 GeneCards: STAG1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	136,752,403 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	100,841,428 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; parotid gland; ; sural nerve; ; synovial joint; ; ganglionic eminence; ; pericardium; ; superficial temporal artery; ; secondary oocyte; ; saphenous vein; ; caput epididymis;
	Top expressed in
	ureter; ; medial ganglionic eminence; ; cumulus cell; ; spermatocyte; ; abdominal wall; ; maxillary prominence; ; dermis; ; primitive streak; ; condyle; ; vas deferens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; protein binding;
Cellular component	chromosome; cytosol; chromatin; chromosome, centromeric region; nucleus; nucleoplasm; nuclear body; cohesin complex; nuclear matrix; mitotic spindle pole;
Biological process	chromosome segregation; cell division; cell cycle; transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of mitotic spindle assembly; sister chromatid cohesion;
	Sources:Amigo / QuickGO
Orthologs
	10274
	20842
	ENSG00000118007
	ENSMUSG00000037286
	Q8WVM7
	Q9D3E6
	NM_005862
	NM_009282; NM_001357264; NM_001357265
	NP_005853
	NP_033308; NP_001344193; NP_001344194
	Wikidata
View/Edit Human	View/Edit Mouse

Cohesin subunit SA-1 (SA1) is a protein that in humans is encoded by the STAG1 gene. SA1 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3. There is a nonprofit community formed for those with a STAG1 Gene mutation at www.stag1gene.org.

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