SMC3

SMC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WD5
Identifiers
Aliases	SMC3, BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes 3
External IDs	OMIM: 606062 MGI: 1339795 HomoloGene: 3974 GeneCards: SMC3
Gene location (Human)
Chr.	Chromosome 10 (human)
End	110,606,048 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	53,634,264 bp
RNA expression pattern
	Top expressed in
	oocyte; ; ganglionic eminence; ; internal globus pallidus; ; Achilles tendon; ; secondary oocyte; ; superior surface of tongue; ; lactiferous duct; ; pylorus; ; pericardium; ; optic nerve;
	Top expressed in
	maxillary prominence; ; hand; ; secondary oocyte; ; somite; ; ganglionic eminence; ; dermis; ; thymus; ; foot; ; yolk sac; ; primitive streak;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; mediator complex binding; chromatin binding; protein binding; protein heterodimerization activity; ATP binding; dynein complex binding; beta-tubulin binding; protein-containing complex binding;
Cellular component	cytosol; meiotic cohesin complex; nuclear matrix; chromosome; nucleoplasm; lateral element; chromatin; chromosome, centromeric region; nucleus; basement membrane; intracellular anatomical structure; cohesin complex; mitotic spindle pole;
Biological process	regulation of DNA replication; chromosome organization; cellular response to DNA damage stimulus; stem cell population maintenance; cell division; negative regulation of DNA endoreduplication; cell cycle; DNA repair; sister chromatid cohesion; mitotic cell cycle; meiosis; regulation of mitotic spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	9126
	13006
	ENSG00000108055
	ENSMUSG00000024974
	Q9UQE7
	Q9CW03
	NM_005445
	NM_007790
	NP_005436
	NP_031816
	Wikidata
View/Edit Human	View/Edit Mouse

Structural maintenance of chromosomes protein 3 (SMC3) is a protein that in humans is encoded by the SMC3 gene. SMC3 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. In humans, SMC3 is present in all cohesin complexes whereas there are multiple paralogs for the other subunits.

SMC3 is a member of the SMC protein family. Members of this family are key regulators of DNA repair, chromosome condensation and chromosome segregation.

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