REC8

REC8
Identifiers
Aliases	REC8, HR21spB, REC8L1, Rec8p, REC8 meiotic recombination protein
External IDs	OMIM: 608193 MGI: 1929645 HomoloGene: 3768 GeneCards: REC8
Gene location (Human)
Chr.	Chromosome 14 (human)
End	24,180,257 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,862,852 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; ganglionic eminence; ; right uterine tube; ; bone marrow; ; gallbladder; ; body of stomach; ; bone marrow cells; ; spleen; ; fundus; ; hypothalamus;
	Top expressed in
	spermatid; ; seminiferous tubule; ; duodenum; ; urethra; ; islet of Langerhans; ; seminal vesicula; ; morula; ; adrenal gland; ; Paneth cell; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chromatin binding;
Cellular component	male germ cell nucleus; chromosome; lateral element; condensed nuclear chromosome; nuclear chromosome; synaptonemal complex; chromosome, centromeric region; nucleus; condensed chromosome; meiotic cohesin complex; cohesin complex;
Biological process	reciprocal meiotic recombination; chromosome segregation; male meiosis I; sister chromatid cohesion; seminiferous tubule development; homologous chromosome pairing at meiosis; oocyte maturation; double-strand break repair via homologous recombination; synaptonemal complex assembly; spermatogenesis; spermatid development; fertilization; double-strand break repair; meiosis;
	Sources:Amigo / QuickGO
Orthologs
	9985
	56739
	ENSG00000100918
	ENSMUSG00000002324
	O95072
	Q8C5S7
	NM_001048205; NM_005132
	NM_020002; NM_001360389; NM_001360390
	NP_001041670; NP_005123
	NP_064386; NP_001347318; NP_001347319
	Wikidata
View/Edit Human	View/Edit Mouse

Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.

Rec8 is a meiosis-specific component of the cohesin complex that binds sister chromatids in preparation for the two divisions of meiosis. Rec8 is sequentially removed from sister chromatids. It is removed from the arms of chromosomes in the first division - separating homologous chromosomes from each other. However, Rec8 is maintained at centromeres so that sister chromatids are kept joined until anaphase of meiosis II, at which point removal of remaining cohesin leads to the separation of sister chromatids.

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