Band 3 anion transport protein

Search for
Structures	Swiss-model
Domains	InterPro

solute carrier family 4 (anion exchanger), member 1, adapter protein
solute carrier family 4 (anion exchanger), member 1, adapter protein
Identifiers
Symbol	SLC4A1AP
NCBI gene	22950
HGNC	13813
OMIM	602655
RefSeq	NM_018158
UniProt	P02730
Other data
Locus	Chr. 2 p23.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

SLC4A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BH7, 1BNX, 1BTQ, 1BTR, 1BTS, 1BTT, 1BZK, 1HYN, 3BTB, 2BTA, 2BTB, 4KY9, 4YZF
Identifiers
Aliases	SLC4A1, solute carrier family 4 (anion exchanger), member 1 (Diego blood group), AE1, BND3, CD233, DI, EMPB3, EPB3, FR, RTA1A, SW, WD, WD1, WR, CHC, SAO, SPH4, solute carrier family 4 member 1 (Diego blood group)
External IDs	OMIM: 109270 MGI: 109393 HomoloGene: 133556 GeneCards: SLC4A1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,268,141 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,257,029 bp
RNA expression pattern
	Top expressed in
	spongy bone; ; bone marrow; ; bone marrow cells; ; renal medulla; ; blood; ; kidney; ; monocyte; ; kidney tubule; ; vena cava; ; glomerulus;
	Top expressed in
	blood; ; internal carotid artery; ; body of femur; ; external carotid artery; ; yolk sac; ; endocardial cushion; ; spleen; ; belly cord; ; fossa; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein-membrane adaptor activity; chloride transmembrane transporter activity; transporter activity; anion transmembrane transporter activity; bicarbonate transmembrane transporter activity; protein binding; ankyrin binding; inorganic anion exchanger activity; sodium:bicarbonate symporter activity; hemoglobin binding;
Cellular component	integral component of membrane; blood microparticle; membrane; cortical cytoskeleton; plasma membrane; integral component of plasma membrane; basolateral plasma membrane; extracellular exosome; Z disc; cytoplasmic side of plasma membrane;
Biological process	anion transport; bicarbonate transport; cellular ion homeostasis; chloride transport; ion transport; regulation of intracellular pH; anion transmembrane transport; chloride transmembrane transport; sodium ion transmembrane transport; transport; glycolytic process; blood coagulation; plasma membrane phospholipid scrambling; negative regulation of urine volume; pH elevation; erythrocyte development; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	6521
	20533
	ENSG00000004939
	ENSMUSG00000006574
	P02730
	P04919
	NM_000342
	NM_011403
	NP_000333
	NP_035533
	Wikidata
View/Edit Human	View/Edit Mouse

Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), is a protein that is encoded by the SLC4A1 gene in humans.

Band 3 anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of chloride (Cl⁻) with bicarbonate (HCO₃⁻) across plasma membranes. Functionally similar members of the AE clade are AE2 and AE3.

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