Anion exchange protein 3

SLC4A3
Identifiers
Aliases	SLC4A3, AE3, SLC2C, CAE3/BAE3, solute carrier family 4 member 3
External IDs	OMIM: 106195 MGI: 109350 HomoloGene: 129474 GeneCards: SLC4A3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	219,641,980 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	75,538,816 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; right ventricle; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; pituitary gland; ; anterior pituitary; ; frontal pole; ; amygdala; ; middle frontal gyrus;
	Top expressed in
	entorhinal cortex; ; interventricular septum; ; right ventricle; ; myocardium of ventricle; ; cardiac muscles; ; pontine nuclei; ; cingulate gyrus; ; superior frontal gyrus; ; visual cortex; ; facial motor nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antiporter activity; inorganic anion exchanger activity; anion transmembrane transporter activity; sodium:bicarbonate symporter activity;
Cellular component	integral component of membrane; integral component of plasma membrane; plasma membrane; membrane;
Biological process	anion transport; regulation of intracellular pH; ion transport; inorganic anion transport; bicarbonate transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6508
	20536
	ENSG00000114923
	ENSMUSG00000006576
	P48751
	P16283
	NM_005070; NM_201574; NM_001326559
	NM_009208; NM_001357149; NM_001357150
	NP_001313488; NP_005061; NP_963868
	NP_033234; NP_001344078; NP_001344079
	Wikidata
View/Edit Human	View/Edit Mouse

Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally similar to the Band 3 Cl⁻/HCO3⁻ exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 mutations have been linked to seizures.

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