Addressin

MADCAM1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1BQS, 1GSM, 4HBQ, 4HC1, 4HCR, 4HD9
Identifiers
Aliases	MADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDs	OMIM: 102670 GeneCards: MADCAM1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	505,343 bp
RNA expression pattern
	Top expressed in
	appendix; ; spleen; ; cingulate gyrus; ; Brodmann area 9; ; prefrontal cortex; ; cardia; ; fundus; ; amygdala; ; body of stomach; ; duodenum;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	integrin binding involved in cell-matrix adhesion;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	leukocyte tethering or rolling; heterotypic cell-cell adhesion; cell adhesion; cell-matrix adhesion; extracellular matrix organization; receptor clustering; immune response; signal transduction; regulation of immune response; positive regulation of leukocyte migration; integrin-mediated signaling pathway; positive regulation of lymphocyte migration;
	Sources:Amigo / QuickGO
Orthologs
	8174
	n/a
	ENSG00000099866
	n/a
	Q13477
	n/a
	NM_130762; NM_130760
	n/a
	NP_570116; NP_570118
	n/a
	Wikidata
View/Edit Human

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene. The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.

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