Integrin alpha 7

ITGA7
Identifiers
Aliases	ITGA7, integrin subunit alpha 7
External IDs	OMIM: 600536 MGI: 102700 HomoloGene: 37592 GeneCards: ITGA7
Gene location (Human)
Chr.	Chromosome 12 (human)
End	55,716,404 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,794,151 bp
RNA expression pattern
	Top expressed in
	right coronary artery; ; ascending aorta; ; saphenous vein; ; popliteal artery; ; left ventricle; ; left coronary artery; ; abdominal fat; ; subcutaneous adipose tissue; ; tibial nerve; ; left uterine tube;
	Top expressed in
	ankle; ; outer renal medulla; ; inner stripe of outer renal medulla; ; external carotid artery; ; lip; ; striated muscle tissue; ; skeletal muscle tissue; ; myocardium of ventricle; ; cardiac muscles; ; thoracic diaphragm;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; metal ion binding;
Cellular component	integral component of membrane; cell surface; integrin complex; plasma membrane; membrane;
Biological process	integrin-mediated signaling pathway; heterotypic cell-cell adhesion; muscle organ development; cell-matrix adhesion; extracellular matrix organization; cell adhesion; endodermal cell differentiation; regulation of cell shape;
	Sources:Amigo / QuickGO
Orthologs
	3679
	16404
	ENSG00000135424
	ENSMUSG00000025348
	Q13683
	Q61738
NM_001144996; NM_001144997; NM_002206; NM_001367993; NM_001367994;
	NM_001374465
	NM_008398; NM_001330160
NP_001138468; NP_001138469; NP_002197; NP_001354922; NP_001354923;
	NP_001361394
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures. Mutations in ITGA7 have been associated with congenital myopathies and noncompaction cardiomyopathy, and altered expression levels of alpha-7 integrin have been identified in various forms of muscular dystrophy.

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