Integrin beta 7

ITGB7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BRQ, 3V4P, 3V4V
Identifiers
Aliases	ITGB7, integrin subunit beta 7
External IDs	OMIM: 147559 MGI: 96616 HomoloGene: 20247 GeneCards: ITGB7
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,207,282 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,140,379 bp
RNA expression pattern
	Top expressed in
	lymph node; ; bone marrow cells; ; blood; ; spleen; ; cecum; ; appendix; ; monocyte; ; trachea; ; cardia; ; pylorus;
	Top expressed in
	blood; ; spleen; ; thymus; ; morula; ; corneal stroma; ; bone marrow; ; subcutaneous adipose tissue; ; ankle joint; ; sciatic nerve; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; metal ion binding; protein binding; cell adhesion molecule binding; integrin binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; receptor complex; plasma membrane; cell surface; integrin complex; extracellular exosome; integrin alpha4-beta7 complex; focal adhesion;
Biological process	T cell migration; heterotypic cell-cell adhesion; cell-matrix adhesion involved in ameboidal cell migration; extracellular matrix organization; receptor clustering; cell adhesion; regulation of immune response; leukocyte tethering or rolling; integrin-mediated signaling pathway; viral entry into host cell; substrate adhesion-dependent cell spreading; cell-matrix adhesion; leukocyte migration; cell migration; cell adhesion mediated by integrin;
	Sources:Amigo / QuickGO
Orthologs
	3695
	16421
	ENSG00000139626
	ENSMUSG00000001281
	P26010
	P26011
	NM_000889
	NM_013566
	NP_000880
	NP_038594
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α₄β₇, or with ITGAE (CD103) to form α_Eβ₇.

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