ICAM-1

ICAM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
Identifiers
Aliases	ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1
External IDs	OMIM: 147840 MGI: 96392 HomoloGene: 168 GeneCards: ICAM1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,286,615 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,940,113 bp
RNA expression pattern
	Top expressed in
	vena cava; ; upper lobe of left lung; ; right lung; ; gallbladder; ; lower lobe of lung; ; spleen; ; monocyte; ; lymph node; ; left uterine tube; ; appendix;
	Top expressed in
	right lung lobe; ; left lung; ; left lung lobe; ; spleen; ; ankle joint; ; thymus; ; aortic valve; ; yolk sac; ; calvaria; ; carotid body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	virus receptor activity; protein-containing complex binding; integrin binding; protein binding; transmembrane signaling receptor activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; focal adhesion; plasma membrane; integral component of plasma membrane; cell surface; immunological synapse; membrane raft; extracellular exosome; external side of plasma membrane; extracellular space; extracellular matrix; collagen-containing extracellular matrix;
Biological process	leukocyte cell-cell adhesion; response to ionizing radiation; establishment of endothelial barrier; negative regulation of endothelial cell apoptotic process; cellular response to organic substance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; response to amino acid; response to hypoxia; positive regulation of actin filament polymerization; response to organic cyclic compound; T cell antigen processing and presentation; establishment of Sertoli cell barrier; response to sulfur dioxide; response to copper ion; interferon-gamma-mediated signaling pathway; positive regulation of nitric oxide biosynthetic process; response to amphetamine; cellular response to tumor necrosis factor; regulation of leukocyte mediated cytotoxicity; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; extracellular matrix organization; acute inflammatory response to antigenic stimulus; sensory perception of sound; cellular response to alkaloid; response to gonadotropin; positive regulation of cellular extravasation; positive regulation of GTPase activity; response to lipopolysaccharide; regulation of cell adhesion; cell adhesion; cell adhesion mediated by integrin; positive regulation of NF-kappaB transcription factor activity; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of vasoconstriction; cellular response to interleukin-1; cellular response to nutrient levels; negative regulation of calcium ion transport; regulation of cell shape; membrane to membrane docking; positive regulation of peptidyl-tyrosine phosphorylation; ovarian follicle development; regulation of immune response; positive regulation of ERK1 and ERK2 cascade; regulation of ruffle assembly; viral entry into host cell; response to ethanol; viral process; cellular response to lipopolysaccharide; cellular response to hypoxia; leukocyte migration; cellular response to glucose stimulus; response to insulin; cellular response to interferon-gamma; cellular response to interleukin-6; cellular response to dexamethasone stimulus; establishment of endothelial intestinal barrier; positive regulation of leukocyte adhesion to vascular endothelial cell; cellular response to leukemia inhibitory factor; cell-cell adhesion; cytokine-mediated signaling pathway; T cell extravasation; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	3383
	15894
	ENSG00000090339
	ENSMUSG00000037405
	P05362
	P13597
	NM_000201
	NM_010493
	NP_000192
	NP_034623
	Wikidata
View/Edit Human	View/Edit Mouse

ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into respiratory epithelium.

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