XIAP

XIAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1F9X, 1G3F, 1G73, 1I3O, 1I4O, 1I51, 1KMC, 1NW9, 1TFQ, 1TFT, 2ECG, 2JK7, 2KNA, 2OPY, 2OPZ, 2POI, 2POP, 2QRA, 2VSL, 3CLX, 3CM2, 3CM7, 3EYL, 3G76, 3HL5, 3UW4, 3UW5, 4EC4, 4HY0, 4IC2, 4IC3, 4J3Y, 4J44, 4J45, 4J46, 4J47, 4J48, 4KJU, 4KJV, 4KMP, 4MTZ, 4OXC, 4WVS, 4WVT, 4WVU, 5C0K, 5C0L, 5C3H, 5C3K, 5C7A, 5C7B, 5C7C, 5C7D, 5C83, 5C84
Identifiers
Aliases	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, X-linked inhibitor of apoptosis
External IDs	OMIM: 300079 MGI: 107572 HomoloGene: 901 GeneCards: XIAP
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	41,198,533 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; jejunal mucosa; ; corpus epididymis; ; tibialis anterior muscle; ; corpus callosum; ; nipple; ; pylorus; ; seminal vesicula; ; subthalamic nucleus; ; cardia;
	Top expressed in
	left lung lobe; ; retinal pigment epithelium; ; cerebellar vermis; ; habenula; ; right lung; ; seminal vesicula; ; atrioventricular valve; ; ventral tegmental area; ; right lung lobe; ; mammillary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ubiquitin-protein transferase activity; peptidase inhibitor activity; cysteine-type endopeptidase inhibitor activity; protein binding; metal ion binding; identical protein binding; transferase activity; ubiquitin protein ligase activity;
Cellular component	nucleus; nucleoplasm; cytosol; cytoplasm;
Biological process	regulation of inflammatory response; mitotic spindle assembly; regulation of cell population proliferation; regulation of innate immune response; negative regulation of peptidase activity; positive regulation of protein linear polyubiquitination; copper ion homeostasis; regulation of nucleotide-binding oligomerization domain containing signaling pathway; cellular response to DNA damage stimulus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of canonical Wnt signaling pathway; regulation of BMP signaling pathway; positive regulation of protein ubiquitination; Wnt signaling pathway; negative regulation of apoptotic process; protein ubiquitination; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	331
	11798
	ENSG00000101966
	ENSMUSG00000025860
	P98170
	Q60989
	NM_001167; NM_001204401
	NM_001301639; NM_001301641; NM_009688
	NP_001158; NP_001191330; NP_001365519; NP_001365520; NP_001365521
	NP_001288568; NP_001288570; NP_033818
	Wikidata
View/Edit Human	View/Edit Mouse

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.

XIAP is a member of the inhibitor of apoptosis family of proteins (IAP). IAPs were initially identified in baculoviruses, but XIAP is one of the homologous proteins found in mammals. It is so called because it was first discovered by a 273 base pair site on the X chromosome. The protein is also called human IAP-like Protein (hILP), because it is not as well conserved as the human IAPS: hIAP-1 and hIAP-2. XIAP is the most potent human IAP protein currently identified.

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