Baculoviral IAP repeat-containing protein 3

BIRC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Identifiers
Aliases	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, baculoviral IAP repeat containing 3, IAP-1
External IDs	OMIM: 601721 MGI: 1197007 HomoloGene: 899 GeneCards: BIRC3
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,339,403 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	7,873,187 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; spleen; ; gallbladder; ; palpebral conjunctiva; ; thymus; ; rectum; ; superficial temporal artery; ; Achilles tendon; ; body of stomach;
	Top expressed in
	secondary oocyte; ; spleen; ; prostate; ; egg cell; ; thymus; ; blood; ; left colon; ; jejunum; ; subcutaneous adipose tissue; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; ubiquitin-protein transferase activity; transferase activity; ubiquitin protein ligase activity;
Cellular component	cytoplasm; nucleoplasm; membrane raft; nucleus; cytosol; protein-containing complex;
Biological process	regulation of apoptotic process; regulation of nucleotide-binding oligomerization domain containing signaling pathway; regulation of innate immune response; regulation of toll-like receptor signaling pathway; negative regulation of necroptotic process; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; regulation of cysteine-type endopeptidase activity; regulation of RIG-I signaling pathway; regulation of tumor necrosis factor-mediated signaling pathway; negative regulation of apoptotic process; tumor necrosis factor-mediated signaling pathway; mitotic spindle assembly; cell surface receptor signaling pathway; NIK/NF-kappaB signaling; spermatogenesis; regulation of inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB signaling; I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; apoptotic process; protein ubiquitination; protein deubiquitination; regulation of necroptotic process; protein heterooligomerization; MyD88-independent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	330
	11796
	ENSG00000023445
	ENSMUSG00000032000
	Q13489
	O08863
	NM_001165; NM_182962
	NM_007464
	NP_001156; NP_892007
	NP_031490
	Wikidata
View/Edit Human	View/Edit Mouse

Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene.

cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.

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