Baculoviral IAP repeat-containing protein 2

BIRC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1QBH, 2L9M, 3D9T, 3D9U, 3M1D, 3MUP, 3OZ1, 3T6P, 3UW4, 4EB9, 4HY4, 4HY5, 4KMN, 4LGE, 4LGU, 4MTI, 4MU7
Identifiers
Aliases	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1, baculoviral IAP repeat containing 2
External IDs	OMIM: 601712 MGI: 1197009 HomoloGene: 900 GeneCards: BIRC2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	102,378,670 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	7,837,065 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; endothelial cell; ; germinal epithelium; ; tibia; ; visceral pleura; ; parietal pleura; ; pancreatic ductal cell; ; corpus epididymis; ; mucosa of urinary bladder; ; trigeminal ganglion;
	Top expressed in
	spermatocyte; ; blood; ; spermatid; ; spleen; ; seminiferous tubule; ; conjunctival fornix; ; pituitary gland; ; thymus; ; cerebellar vermis; ; lacrimal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; metal ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; transferase activity; ubiquitin binding; chaperone binding; FBXO family protein binding; zinc ion binding; transcription coactivator activity; ubiquitin-protein transferase activity; identical protein binding; ubiquitin protein ligase activity;
Cellular component	cytosol; XY body; membrane raft; CD40 receptor complex; cytoplasmic side of plasma membrane; nucleus; cytoplasm; protein-containing complex;
Biological process	regulation of apoptotic process; regulation of nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of protein K63-linked ubiquitination; response to hypoxia; regulation of transcription, DNA-templated; regulation of innate immune response; response to organic cyclic compound; negative regulation of ripoptosome assembly involved in necroptotic process; inhibition of cysteine-type endopeptidase activity involved in apoptotic process; placenta development; regulation of cysteine-type endopeptidase activity; regulation of RIG-I signaling pathway; regulation of tumor necrosis factor-mediated signaling pathway; tumor necrosis factor-mediated signaling pathway; regulation of reactive oxygen species metabolic process; transcription, DNA-templated; positive regulation of protein monoubiquitination; mitotic spindle assembly; cell surface receptor signaling pathway; NIK/NF-kappaB signaling; regulation of cell population proliferation; response to organonitrogen compound; positive regulation of protein K48-linked ubiquitination; response to cAMP; response to ethanol; I-kappaB kinase/NF-kappaB signaling; proteasome-mediated ubiquitin-dependent protein catabolic process; necroptosis; apoptotic process; protein deubiquitination; cellular response to tumor necrosis factor; regulation of NIK/NF-kappaB signaling; positive regulation of protein polyubiquitination; negative regulation of necroptotic process; protein polyubiquitination; regulation of toll-like receptor signaling pathway; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of cell differentiation; regulation of inflammatory response; regulation of cell cycle; regulation of necroptotic process; protein heterooligomerization; positive regulation of nucleic acid-templated transcription; MyD88-independent toll-like receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; positive regulation of protein ubiquitination; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	329
	11797
	ENSG00000110330
	ENSMUSG00000057367
	Q13490
	Q62210
	NM_001256166; NM_001166; NM_001256163
	NM_007465; NM_001291503
	NP_001157; NP_001243092; NP_001243095
	NP_001278432; NP_031491
	Wikidata
View/Edit Human	View/Edit Mouse

Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene.

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