Tissue factor pathway inhibitor

TFPI
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
Identifiers
Aliases	TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
External IDs	OMIM: 152310 MGI: 1095418 HomoloGene: 4579 GeneCards: TFPI
Gene location (Human)
Chr.	Chromosome 2 (human)
End	187,565,760 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	84,307,119 bp
RNA expression pattern
	Top expressed in
	right lung; ; lower lobe of lung; ; visceral pleura; ; upper lobe of lung; ; placenta; ; upper lobe of left lung; ; stromal cell of endometrium; ; liver; ; pericardium; ; right lobe of liver;
	Top expressed in
	placenta; ; atrioventricular valve; ; vas deferens; ; dermis; ; endocardial cushion; ; belly cord; ; external carotid artery; ; atrium; ; yolk sac; ; Paneth cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	organelle membrane; extracellular region; cell surface; anchored component of membrane; plasma membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle; extracellular space; caveola;
Biological process	hemostasis; blood coagulation, extrinsic pathway; negative regulation of peptidase activity; blood coagulation; response to lipopolysaccharide; response to estradiol; cellular response to lipopolysaccharide; negative regulation of endopeptidase activity; cellular response to interleukin-1; negative regulation of blood coagulation; cellular response to steroid hormone stimulus;
	Sources:Amigo / QuickGO
Orthologs
	7035
	21788
	ENSG00000003436
	ENSMUSG00000027082
	P10646
	O54819
NM_001032281; NM_006287; NM_001318941; NM_001329239; NM_001329240;
	NM_001329241
	NM_001177319; NM_001177320; NM_011576; NM_001355271; NM_001355273
NP_001027452; NP_001305870; NP_001316168; NP_001316169; NP_001316170;
	NP_006278
	NP_001170790; NP_001170791; NP_035706; NP_001342200; NP_001342202
	Wikidata
View/Edit Human	View/Edit Mouse

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

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