Tissue factor

F3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AHW, 1BOY, 1DAN, 1FAK, 1J9C, 1JPS, 1O5D, 1TFH, 1UJ3, 1W0Y, 1W2K, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2C4F, 2CEF, 2CEH, 2CEZ, 2CFJ, 2EC9, 2F9B, 2FIR, 2FLB, 2HFT, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4M7L, 4Z6A, 4ZMA, 4YLQ, 2FLR
Identifiers
Aliases	F3, CD142, TF, TFA, coagulation factor III, tissue factor
External IDs	OMIM: 134390 MGI: 88381 HomoloGene: 1511 GeneCards: F3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	94,541,759 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	121,528,697 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; amniotic fluid; ; stromal cell of endometrium; ; left uterine tube; ; lower lobe of lung; ; gallbladder; ; trachea; ; minor salivary gland; ; anterior pituitary; ; seminal vesicula;
	Top expressed in
	Eustachian tube; ; corneal stroma; ; cervix; ; respiratory epithelium; ; olfactory epithelium; ; esophagus; ; conjunctival fornix; ; stria vascularis; ; corneal epithelium; ; retinal pigment epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor activity; phospholipid binding; serine-type endopeptidase activity; protease binding;
Cellular component	membrane; extracellular matrix; intrinsic component of external side of plasma membrane; plasma membrane; extracellular region; extracellular exosome; cell surface; extracellular space; serine-type peptidase complex; integral component of membrane; collagen-containing extracellular matrix;
Biological process	hemostasis; positive regulation of protein kinase B signaling; positive regulation of endothelial cell proliferation; cytokine-mediated signaling pathway; positive regulation of cell migration; activation of blood coagulation via clotting cascade; positive regulation of platelet-derived growth factor receptor signaling pathway; positive regulation of angiogenesis; blood coagulation, extrinsic pathway; activation of plasma proteins involved in acute inflammatory response; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of positive chemotaxis; blood coagulation; protein processing;
	Sources:Amigo / QuickGO
Orthologs
	2152
	14066
	ENSG00000117525
	ENSMUSG00000028128
	P13726
	P20352
	NM_001993; NM_001178096
	NM_010171
	NP_001171567; NP_001984
	NP_034301
	Wikidata
View/Edit Human	View/Edit Mouse

Tissue factor, also called platelet tissue factor, factor III, or CD142, is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes. Its role in the clotting process is the initiation of thrombin formation from the zymogen prothrombin. Thromboplastin defines the cascade that leads to the activation of factor X—the tissue factor pathway. In doing so, it has replaced the previously named extrinsic pathway in order to eliminate ambiguity.

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