Coagulation factor VII

F7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YT7, 1BF9, 1CVW, 1DAN, 1DVA, 1F7E, 1F7M, 1FAK, 1FF7, 1FFM, 1J9C, 1JBU, 1KLI, 1KLJ, 1O5D, 1QFK, 1W0Y, 1W2K, 1W7X, 1W8B, 1WQV, 1WSS, 1WTG, 1WUN, 1WV7, 1YGC, 1Z6J, 2A2Q, 2AEI, 2AER, 2B7D, 2B8O, 2BZ6, 2C4F, 2EC9, 2F9B, 2FIR, 2FLB, 2FLR, 2PUQ, 2ZP0, 2ZWL, 2ZZU, 3ELA, 3TH2, 3TH3, 3TH4, 4IBL, 4ISH, 4ISI, 4JYU, 4JYV, 4JZD, 4JZE, 4JZF, 4NA9, 4NG9, 4NGA, 4X8S, 4X8T, 4X8U, 4X8V, 4YT6, 4ZXX, 4ZXY, 4Z6A, 4ZMA, 4YLQ, 5I46
Identifiers
Aliases	F7, SPCA, coagulation factor VII
External IDs	OMIM: 613878 MGI: 109325 HomoloGene: 7710 GeneCards: F7
Gene location (Human)
Chr.	Chromosome 13 (human)
End	113,120,685 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,085,809 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; ventral tegmental area; ; secondary oocyte; ; visceral pleura; ; pancreatic ductal cell; ; deltoid muscle; ; jejunum; ; retinal pigment epithelium; ; occipital lobe; ; superior frontal gyrus;
	Top expressed in
	left lobe of liver; ; right lung lobe; ; yolk sac; ; entorhinal cortex; ; carotid body; ; left lung; ; sexually immature organism; ; thoracic diaphragm; ; dentate gyrus; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; endopeptidase activity; peptidase activity; protein binding; serine-type peptidase activity; hydrolase activity; serine-type endopeptidase activity; signaling receptor binding;
Cellular component	vesicle; endoplasmic reticulum lumen; plasma membrane; extracellular region; Golgi lumen; extracellular space; serine-type peptidase complex; collagen-containing extracellular matrix;
Biological process	hemostasis; positive regulation of protein kinase B signaling; response to organic cyclic compound; positive regulation of cell migration; positive regulation of platelet-derived growth factor receptor signaling pathway; proteolysis; response to estrogen; positive regulation of leukocyte chemotaxis; endoplasmic reticulum to Golgi vesicle-mediated transport; response to vitamin K; positive regulation of blood coagulation; response to nutrient levels; animal organ regeneration; response to growth hormone; response to hormone; blood coagulation, extrinsic pathway; positive regulation of positive chemotaxis; response to thyroid hormone; protein processing; blood coagulation; response to 2,3,7,8-tetrachlorodibenzodioxine; response to estradiol; response to carbon dioxide; response to genistein; response to cholesterol; circadian rhythm; response to thyroxine; response to Thyroid stimulating hormone; response to hypoxia; response to anticoagulant; response to astaxanthin; response to thyrotropin-releasing hormone;
	Sources:Amigo / QuickGO
Orthologs
	2155
	14068
	ENSG00000057593
	ENSMUSG00000031443
	P08709
	P70375
	NM_000131; NM_001267554; NM_019616
	NM_010172
	NP_000122; NP_001254483; NP_062562
	NP_034302
	Wikidata
View/Edit Human	View/Edit Mouse

Coagulation factor VII (EC 3.4.21.21, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade, and in humans is coded for by the gene F7. It is an enzyme of the serine protease class. Once bound to tissue factor released from damaged tissues, it is converted to factor VIIa (or blood-coagulation factor VIIa, activated blood coagulation factor VII), which in turn activates factor IX and factor X.

Using genetic recombination a recombinant factor VIIa (eptacog alfa) (trade names include NovoSeven) has been approved by the FDA for the control of bleeding in hemophilia. It is sometimes used unlicensed in severe uncontrollable bleeding, although there have been safety concerns. A biosimilar form of recombinant activated factor VII (AryoSeven) is also available, but does not play any considerable role in the market.

In April 2020, the US FDA approved a new rFVIIa product, eptacog beta (SEVENFACT), the first bypassing agent (BPA) approved in more than 2 decades. As an rFVIIa product, eptacog beta works in a complex with tissue factor to activate factor X to Xa, thereby bypassing FVIII and FIX. The activation of Factor X to Xa initiates the coagulation cascade’s common pathway, leading to clot formation at the site of hemorrhage. Activated FVII binds to endothelial protein C receptor (EPCR), which enhances hemostasis.14 One study showed that eptacog beta binds to EPCR with 25% to 30% more affinity than eptacog alfa, displacing protein C from EPCR binding sites and downregulating activated protein C generation, contributing to its hemostatic effect.

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