SRD5A1

SRD5A1
Identifiers
Aliases	SRD5A1, S5AR 1, steroid 5 alpha-reductase 1
External IDs	OMIM: 184753 MGI: 98400 HomoloGene: 37426 GeneCards: SRD5A1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	6,674,386 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	69,759,561 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; vulva; ; hair follicle; ; Brodmann area 23; ; jejunal mucosa; ; right lobe of liver; ; cavity of mouth; ; skin of abdomen; ; human penis; ; monocyte;
	Top expressed in
	left lobe of liver; ; otolith organ; ; utricle; ; interventricular septum; ; molar; ; hand; ; lip; ; proximal tubule; ; neural tube; ; foot;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; cholestenone 5-alpha-reductase activity; amide binding; NADPH binding; electron transfer activity; oxidoreductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity;
Cellular component	cytoplasm; integral component of membrane; organelle membrane; endoplasmic reticulum membrane; cell body fiber; membrane; myelin sheath; intracellular membrane-bounded organelle; neuronal cell body; endoplasmic reticulum; perinuclear region of cytoplasm;
Biological process	response to fungicide; cell differentiation; pituitary gland development; male gonad development; response to estradiol; response to organic cyclic compound; circadian sleep/wake cycle, REM sleep; androgen metabolic process; thalamus development; lipid metabolism; cellular response to testosterone stimulus; diterpenoid metabolic process; response to testosterone; cellular response to starvation; cellular response to growth factor stimulus; cellular response to estradiol stimulus; cellular response to organic cyclic compound; sex differentiation; serotonin metabolic process; cellular response to dexamethasone stimulus; response to estrogen; cellular response to epinephrine stimulus; sex-determination system; response to growth hormone; spinal cord development; hypothalamus development; cerebral cortex development; cellular response to insulin stimulus; urogenital system development; liver development; bone development; hippocampus development; response to muscle activity; response to follicle-stimulating hormone; cellular response to cAMP; steroid metabolic process; androgen biosynthetic process; male genitalia development; female genitalia development; progesterone metabolic process; steroid biosynthetic process; electron transport chain; androgen catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6715
	78925
	ENSG00000145545
	ENSMUSG00000021594
	P18405
	Q68FF9
	NM_001047; NM_001324322; NM_001324323
	NM_175283
	NP_001038; NP_001311251; NP_001311252
	NP_780492
	Wikidata
View/Edit Human	View/Edit Mouse

3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. It is one of three forms of steroid 5α-reductase.

Steroid 5α-reductase (EC 1.3.99.5) catalyzes, among other reactions, the conversion of testosterone into the more potent androgen, 5α-dihydrotestosterone (DHT). The SRD5A1, SRD5A2, and SRD5A3 genes in humans all encode 5α-reductase isozymes.

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