SRD5A2

SRD5A2
Identifiers
Aliases	SRD5A2, entrez:6716, steroid 5 alpha-reductase 2
External IDs	OMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	31,580,938 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	74,354,911 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; bronchial epithelial cell; ; right uterine tube; ; liver; ; right lobe of liver; ; caput epididymis; ; prostate; ; seminal vesicula; ; urethra; ; vagina;
	Top expressed in
	adrenal gland; ; olfactory epithelium; ; proximal tubule; ; ejaculatory duct; ; female urethra; ; seminal vesicula; ; kidney; ; left colon; ; secondary oocyte; ; left lobe of liver;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; sterol 5-alpha reductase activity; cholestenone 5-alpha-reductase activity; amide binding; oxidoreductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity; testosterone dehydrogenase [NAD(P) activity];
Cellular component	cytoplasm; organelle membrane; integral component of membrane; membrane; cell body fiber; intracellular membrane-bounded organelle; neuronal cell body; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	cell differentiation; male gonad development; phthalate metabolic process; biphenyl metabolic process; response to organic cyclic compound; lipid metabolism; response to testosterone; response to steroid hormone; cell-cell signaling; response to peptide hormone; sex differentiation; response to organic substance; steroid catabolic process; response to nutrient levels; dibenzo-p-dioxin metabolic process; hypothalamus development; bone development; hippocampus development; response to follicle-stimulating hormone; androgen metabolic process; steroid metabolic process; androgen biosynthetic process; male genitalia development; female genitalia development; progesterone metabolic process; testosterone biosynthetic process; steroid biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	6716
	94224
	ENSG00000277893
	ENSMUSG00000038541
	P31213
	Q99N99
	NM_000348
	NM_053188
	NP_000339
	NP_444418
	Wikidata
View/Edit Human	View/Edit Mouse

The human gene SRD5A2 encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase.

5αR2 catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.

5αR2 is a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The enzyme is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in 5αR2 activity of the can lead to a condition known as 5α-reductase 2 deficiency, which is a cause of 46,XY DSD that presents as atypical male genitalia.

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