Relaxin
Relaxin is a protein hormone of about 6000 Da, first described in 1926 by Frederick Hisaw.
| Relaxin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN1 | ||||||
| Alt. symbols | H1 | ||||||
| NCBI gene | 6013 | ||||||
| HGNC | 10026 | ||||||
| OMIM | 179730 | ||||||
| RefSeq | NM_006911 | ||||||
| UniProt | P04808 | ||||||
| Other data | |||||||
| Locus | Chr. 9 qter-q12 | ||||||
| |||||||
| Relaxin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN2 | ||||||
| Alt. symbols | H2, RLXH2, bA12D24.1.1, bA12D24.1.2 | ||||||
| NCBI gene | 6019 | ||||||
| HGNC | 10027 | ||||||
| OMIM | 179740 | ||||||
| PDB | 6RLX | ||||||
| RefSeq | NM_134441 | ||||||
| UniProt | P04090 | ||||||
| Other data | |||||||
| Locus | Chr. 9 qter-q12 | ||||||
| |||||||
| Relaxin 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | RLN3 | ||||||
| Alt. symbols | ZINS4, RXN3, H3 | ||||||
| NCBI gene | 117579 | ||||||
| HGNC | 17135 | ||||||
| OMIM | 606855 | ||||||
| RefSeq | NM_080864 | ||||||
| UniProt | Q8WXF3 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.3 | ||||||
| |||||||
The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (RLN3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, and INSL6 remain uncharacterised.
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