Osteocalcin

BGLAP
Identifiers
Aliases	BGLAP, BGP, OC, OCN, bone gamma-carboxyglutamate protein, Osteocalcin
External IDs	OMIM: 112260 MGI: 88155 HomoloGene: 104130 GeneCards: BGLAP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,243,317 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,280,050 bp
RNA expression pattern
	Top expressed in
	putamen; ; substantia nigra; ; caudate nucleus; ; nucleus accumbens; ; right uterine tube; ; amygdala; ; hypothalamus; ; right lobe of liver; ; hippocampus proper; ; spleen;
	Top expressed in
	esophagus; ; cochlea; ; lip; ; placenta; ; lymph node; ; stomach; ; white adipose tissue; ; thyroid gland; ; morula; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; structural molecule activity; metal ion binding; hydroxyapatite binding; structural constituent of bone;
Cellular component	cytoplasm; perikaryon; rough endoplasmic reticulum; Golgi apparatus; cell projection; endoplasmic reticulum lumen; extracellular region; dendrite; Golgi lumen; extracellular space; vesicle;
Biological process	skeletal system development; bone mineralization; response to vitamin D; response to organic cyclic compound; ossification; response to testosterone; regulation of bone mineralization; biomineral tissue development; cellular response to growth factor stimulus; response to mechanical stimulus; human ageing; response to zinc ion; response to glucocorticoid; cellular response to vitamin D; response to activity; response to estrogen; odontogenesis; endoplasmic reticulum to Golgi vesicle-mediated transport; response to gravity; response to vitamin K; response to hydroxyisoflavone; cell adhesion; response to nutrient levels; regulation of osteoclast differentiation; osteoblast differentiation; response to inorganic substance; osteoblast development; response to ethanol; regulation of bone resorption; bone development; regulation of cellular response to insulin stimulus;
	Sources:Amigo / QuickGO
Orthologs
	632
	12095
	ENSG00000242252
	ENSMUSG00000074489
	P02818
	P54615
	NM_199173
	NM_031368; NM_001305448; NM_001305449; NM_001305450
	NP_954642
	NP_001292377; NP_001292378; NP_001292379; NP_112736
	Wikidata
View/Edit Human	View/Edit Mouse

Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein.

Because osteocalcin has gla domains, its synthesis is vitamin K dependent. In humans, osteocalcin is encoded by the BGLAP gene. Its receptors include GPRC6A, GPR158, and possibly a third, yet-to-be-identified receptor. There is evidence that GPR37 might be the third osteocalcin receptor.

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