GPR37

GPR37
Identifiers
Aliases	GPR37, EDNRBL, PAELR, hET(B)R-LP, G protein-coupled receptor 37
External IDs	OMIM: 602583 MGI: 1313297 HomoloGene: 3875 GeneCards: GPR37
Gene location (Human)
Chr.	Chromosome 7 (human)
End	124,765,792 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	25,690,728 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; inferior ganglion of vagus nerve; ; optic nerve; ; middle frontal gyrus; ; subthalamic nucleus; ; medulla oblongata; ; ventral tegmental area; ; superior vestibular nucleus; ; external globus pallidus; ; inferior olivary nucleus;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; utricle; ; pontine nuclei; ; medial geniculate nucleus; ; anterior horn of spinal cord; ; ventral tegmental area; ; dorsal tegmental nucleus; ; medial vestibular nucleus; ; lateral hypothalamus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled peptide receptor activity; G protein-coupled receptor activity; heat shock protein binding; prosaposin receptor activity; peptide binding; signal transducer activity; Hsp70 protein binding; protein binding; ubiquitin protein ligase binding;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; ubiquitin ligase complex; receptor complex; plasma membrane; integral component of plasma membrane; endoplasmic reticulum;
Biological process	G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; dopamine biosynthetic process; negative regulation of hydrogen peroxide-induced cell death; locomotion involved in locomotory behavior; positive regulation of MAPK cascade; signal transduction; positive regulation of dopamine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2861
	14763
	ENSG00000170775
	ENSMUSG00000039904
	O15354
	Q9QY42
	NM_005302
	NM_010338
	NP_005293
	NP_034468
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene. GPR37 is primarily found in the central nervous system (CNS), with significant expression observed in various CNS regions including the amygdala, basal ganglia (caudate, putamen, and nucleus accumbens), substantia nigra, hippocampus, frontal cortex, and hypothalamus, particularly noteworthy is its exceptionally elevated expression in the spinal cord.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.