Osteonectin

SPARC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BMO, 1NUB, 1SRA, 2V53
Identifiers
Aliases	SPARC, BM-40, ON, OI17, secreted protein acidic and cysteine rich, ONT
External IDs	OMIM: 182120 MGI: 98373 HomoloGene: 31132 GeneCards: SPARC
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,686,975 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,314,009 bp
RNA expression pattern
	Top expressed in
	tibia; ; stromal cell of endometrium; ; periodontal fiber; ; gallbladder; ; trigeminal ganglion; ; olfactory bulb; ; spinal ganglia; ; visceral pleura; ; smooth muscle tissue; ; ascending aorta;
	Top expressed in
	calvaria; ; body of femur; ; ascending aorta; ; aortic valve; ; belly cord; ; carotid body; ; molar; ; vas deferens; ; skin of abdomen; ; skin of back;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; protein binding; extracellular matrix binding; collagen binding; extracellular matrix structural constituent;
Cellular component	cytoplasm; platelet alpha granule; endocytic vesicle lumen; nuclear matrix; plasma membrane; intracellular anatomical structure; basement membrane; cell surface; platelet alpha granule membrane; mitochondrion; platelet alpha granule lumen; nucleus; extracellular space; vesicle; extracellular region; extracellular matrix; synapse; collagen-containing extracellular matrix; glutamatergic synapse;
Biological process	response to cytokine; response to cadmium ion; ossification; lung development; cellular response to growth factor stimulus; response to peptide hormone; platelet degranulation; extracellular matrix organization; response to L-ascorbic acid; response to glucocorticoid; wound healing; receptor-mediated endocytosis; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; response to calcium ion; response to gravity; heart development; response to lipopolysaccharide; response to lead ion; regulation of cell population proliferation; negative regulation of angiogenesis; inner ear development; regulation of cell morphogenesis; response to cAMP; response to ethanol; bone development; signal transduction; pigmentation; regulation of synapse organization;
	Sources:Amigo / QuickGO
Orthologs
	6678
	20692
	ENSG00000113140
	ENSMUSG00000018593
	P09486
	P07214
	NM_003118; NM_001309443; NM_001309444
	NM_009242; NM_001290817
	NP_001296372; NP_001296373; NP_003109
	NP_001277746; NP_033268
	Wikidata
View/Edit Human	View/Edit Mouse

Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene.

Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over-expression and ampullary cancers and chronic pancreatitis has been found.

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