Macrophage-1 antigen

Macrophage-1 antigen (or integrin α_Mβ₂ or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin α_M) and CD18 (integrin β₂).

The integrin α chain is noncovalently bound to the integrin β chain. It binds to iC3b and can be involved in cellular adhesion, binding to the intercellular adhesion molecule-1 (ICAM-1). CR3 causes phagocytosis and destruction of cells opsonized with iC3b. CR3 and CR4 are thought to exhibit overlapping functions; however, the distinct binding sites to iC3b suggests differences in their functions. Additionally, CR3 has been shown to have therapeutic promise.

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