Integrin alpha M

ITGAM
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BHO, 1BHQ, 1IDN, 1IDO, 1JLM, 1M1U, 1MF7, 1N9Z, 1NA5, 2LKE, 2LKJ, 3Q3G, 3QA3, 4M76, 4XW2
Identifiers
Aliases	ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M
External IDs	OMIM: 120980 MGI: 96607 HomoloGene: 526 GeneCards: ITGAM
Gene location (Human)
Chr.	Chromosome 16 (human)
End	31,332,892 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	127,717,663 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spongy bone; ; bone marrow; ; blood; ; bone marrow cells; ; spleen; ; appendix; ; upper lobe of left lung; ; right lung; ; synovial joint;
	Top expressed in
	bone marrow; ; ileum; ; jejunum; ; spleen; ; hippocampus proper; ; esophagus; ; uterus; ; zone of skin; ; white adipose tissue; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; protein heterodimerization activity; heat shock protein binding; amyloid-beta binding; complement component C3b binding; cargo receptor activity;
Cellular component	extracellular exosome; plasma membrane; cell surface; membrane; integral component of membrane; integrin complex; extracellular space; specific granule membrane; tertiary granule membrane; external side of plasma membrane; integrin alphaM-beta2 complex; plasma membrane raft; membrane raft;
Biological process	ectodermal cell differentiation; toll-like receptor 4 signaling pathway; integrin-mediated signaling pathway; leukocyte migration; extracellular matrix organization; cell adhesion; neutrophil degranulation; microglial cell activation; immune system process; receptor-mediated endocytosis; phagocytosis, engulfment; cytokine-mediated signaling pathway; positive regulation of superoxide anion generation; positive regulation of neutrophil degranulation; innate immune response; negative regulation of dopamine metabolic process; positive regulation of protein targeting to membrane; amyloid-beta clearance; cell-cell adhesion via plasma-membrane adhesion molecules; complement-mediated synapse pruning; vertebrate eye-specific patterning; positive regulation of neuron death; positive regulation of microglial cell activation; positive regulation of microglial cell mediated cytotoxicity; cell surface receptor signaling pathway involved in cell-cell signaling; positive regulation of prostaglandin-E synthase activity; forebrain development; apoptotic signaling pathway; positive regulation of hippocampal neuron apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	3684
	16409
	ENSG00000169896
	ENSMUSG00000030786
	P11215
	P05555
	NM_000632; NM_001145808
	NM_001082960; NM_008401
	NP_000623; NP_001139280
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (α_Mβ₂) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of differentiation molecule 11B (CD11B). The second chain of α_Mβ₂ is the common integrin β₂ subunit known as CD18, and integrin α_Mβ₂ thus belongs to the β₂ subfamily (or leukocyte) integrins.

α_Mβ₂ is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells and subsets of T and B cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation. It is involved in the complement system due to its capacity to bind inactivated complement component 3b (iC3b). The ITGAM (alpha) subunit of integrin α_Mβ₂ is directly involved in causing the adhesion and spreading of cells but cannot mediate cellular migration without the presence of the β2 (CD18) subunit.

In genomewide association studies, single nucleotide polymorphisms in ITGAM had the strongest association with systemic lupus erythematosus, with an odds ratio of 1.65 for the T allele of rs9888739 and lupus.

In histopathology, immunohistochemistry with antibodies against CD11B is frequently used to identify macrophages and microglia.

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