MAP2K7

MAP2K7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M
Identifiers
Aliases	MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7
External IDs	OMIM: 603014 MGI: 1346871 HomoloGene: 56548 GeneCards: MAP2K7
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,914,478 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	4,297,897 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; nipple; ; cardia; ; body of tongue; ; gastric mucosa; ; vena cava; ; skin of abdomen; ; canal of the cervix; ; subthalamic nucleus; ; inferior ganglion of vagus nerve;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; median eminence; ; habenula; ; arcuate nucleus; ; lateral geniculate nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; superior colliculus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleotide binding; protein tyrosine kinase activity; protein kinase binding; protein kinase activity; magnesium ion binding; transferase activity; kinase activity; ATP binding; enzyme binding; protein phosphatase binding; protein binding; MAP kinase kinase activity; protein serine/threonine kinase activity; JUN kinase kinase activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	response to UV; signal transduction; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of telomere capping; apoptotic process; response to osmotic stress; peptidyl-tyrosine phosphorylation; response to tumor necrosis factor; protein phosphorylation; response to heat; phosphorylation; stress-activated MAPK cascade; regulation of mitotic cell cycle; regulation of apoptotic process; stress-activated protein kinase signaling cascade; activation of protein kinase activity; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade; JNK cascade; Fc-epsilon receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5609
	26400
	ENSG00000076984
	ENSMUSG00000002948
	O14733
	Q8CE90
	NM_001297555; NM_001297556; NM_145185
NM_001042557; NM_001164172; NM_001291777; NM_001291778; NM_001291783;
	NM_011944
	NP_001284484; NP_001284485; NP_660186
NP_001036022; NP_001157644; NP_001278706; NP_001278707; NP_001278712;
	NP_036074
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (α, β, and γ isoforms) and two possible C-termini (1 and 2 isoforms).

MKK7 is involved in signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK.

MKK7 is ubiquitously expressed in all tissue. However, it displays a higher level of expression in skeletal muscle. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.