MAP4K2

MAP4K2
Identifiers
Aliases	MAP4K2, BL44, GCK, RAB8IP, mitogen-activated protein kinase kinase kinase kinase 2
External IDs	OMIM: 603166 MGI: 1346883 HomoloGene: 3370 GeneCards: MAP4K2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,803,241 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,405,645 bp
RNA expression pattern
	Top expressed in
	spleen; ; right lung; ; monocyte; ; lymph node; ; upper lobe of left lung; ; prefrontal cortex; ; blood; ; cingulate gyrus; ; body of stomach; ; amygdala;
	Top expressed in
	thymus; ; cerebellum; ; spleen; ; cerebellar cortex; ; hypothalamus; ; superior frontal gyrus; ; bone marrow; ; olfactory bulb; ; islet of Langerhans; ; lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; mitogen-activated protein kinase kinase kinase binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; MAP kinase kinase kinase kinase activity;
Cellular component	Golgi apparatus; membrane; Golgi membrane; plasma membrane; basolateral plasma membrane; cytoplasm;
Biological process	intracellular signal transduction; vesicle targeting; phosphorylation; immune system process; positive regulation of JNK cascade; protein phosphorylation; JNK cascade; immune response; innate immune response; regulation of mitotic cell cycle; regulation of apoptotic process; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	5871
	26412
	ENSG00000168067
	ENSMUSG00000024948
	Q12851
	Q61161
	NM_001307990; NM_004579
	NM_001291787; NM_009006
	NP_001294919; NP_004570
	NP_001278716; NP_033032
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.