MAPK8

MAPK8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UKH, 1UKI, 2G01, 2GMX, 2H96, 2NO3, 2XRW, 2XS0, 3ELJ, 3O17, 3O2M, 3PZE, 3V3V, 3VUD, 3VUG, 3VUH, 3VUI, 3VUK, 3VUL, 3VUM, 4AWI, 4E73, 4G1W, 4HYS, 4HYU, 4IZY, 4L7F, 4QTD, 4UX9, 4YR8
Identifiers
Aliases	MAPK8, Mapk8, AI849689, JNK, JNK1, Prkm8, SAPK1, JNK-46, JNK1A2, JNK21B1/2, SAPK1c, mitogen-activated protein kinase 8
External IDs	OMIM: 601158 MGI: 1346861 HomoloGene: 56760 GeneCards: MAPK8
Gene location (Human)
Chr.	Chromosome 10 (human)
End	48,439,360 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	33,169,115 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; stromal cell of endometrium; ; islet of Langerhans; ; internal globus pallidus; ; gallbladder; ; pons; ; rectum; ; prefrontal cortex; ; cerebellar hemisphere;
	Top expressed in
	secondary oocyte; ; barrel cortex; ; superior cervical ganglion; ; ganglionic eminence; ; visual cortex; ; piriform cortex; ; habenula; ; medial dorsal nucleus; ; primary motor cortex; ; medial ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; MAP kinase activity; histone deacetylase binding; histone deacetylase regulator activity; protein serine/threonine kinase activity; protein binding; enzyme binding; ATP binding; JUN kinase activity; kinase activity;
Cellular component	cytosol; nucleoplasm; nucleus; mitochondrion; cytoplasm; neuron projection; axon; basal dendrite;
Biological process	phosphorylation; rhythmic process; response to stress; negative regulation of apoptotic process; negative regulation of protein binding; regulation of protein localization; Fc-epsilon receptor signaling pathway; JNK cascade; cellular response to mechanical stimulus; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of gene expression; JUN phosphorylation; regulation of DNA-binding transcription factor activity; peptidyl-serine phosphorylation; regulation of circadian rhythm; positive regulation of deacetylase activity; peptidyl-threonine phosphorylation; positive regulation of cyclase activity; cellular response to lipopolysaccharide; response to UV; regulation of macroautophagy; regulation of histone deacetylation; positive regulation of apoptotic process; neuron development; protein phosphorylation; cellular response to amino acid starvation; cellular response to reactive oxygen species; stress-activated MAPK cascade; cellular response to cadmium ion; regulation of DNA replication origin binding; response to mechanical stimulus; regulation of gene expression; intracellular signal transduction; cellular response to organic substance; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	5599
	26419
	ENSG00000107643
	ENSMUSG00000021936
	P45983
	Q91Y86
NM_001278547; NM_001278548; NM_002750; NM_139046; NM_139049;
	NM_001323302; NM_001323320; NM_001323321; NM_001323322; NM_001323323; NM_001323324; NM_001323325; NM_001323326; NM_001323327; NM_001323328; NM_001323329; NM_001323330; NM_001323331
	NM_001310452; NM_001310453; NM_001310454; NM_016700
NP_001265476; NP_001265477; NP_001310231; NP_001310249; NP_001310250;
	NP_001310251; NP_001310252; NP_001310253; NP_001310254; NP_001310255; NP_001310256; NP_001310257; NP_001310258; NP_001310259; NP_001310260; NP_620634; NP_620637
	NP_001297381; NP_001297382; NP_001297383; NP_057909
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene.

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