Lefty (protein)
Lefty (left-right determination factors) are a class of proteins that are closely related members of the TGF-beta superfamily of growth factors. These proteins are secreted and play a role in left-right asymmetry determination of organ systems during development. Mutations of the genes encoding these proteins have been associated with left-right axis malformations, particularly in the heart and lungs.
| left-right determination factor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LEFTY1 | ||||||
| Alt. symbols | LEFTB | ||||||
| NCBI gene | 10637 | ||||||
| HGNC | 6552 | ||||||
| OMIM | 603037 | ||||||
| RefSeq | NM_020997 | ||||||
| UniProt | O75610 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q42.1 | ||||||
| |||||||
| left-right determination factor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LEFTY2 | ||||||
| Alt. symbols | TGFB4, EBAF | ||||||
| NCBI gene | 7044 | ||||||
| HGNC | 3122 | ||||||
| OMIM | 601877 | ||||||
| RefSeq | NM_003240 | ||||||
| UniProt | O00292 | ||||||
| Other data | |||||||
| Locus | Chr. 1 q42.1 | ||||||
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