Left-right determination factor 1

LEFTY1
Identifiers
Aliases	LEFTY1, LEFTB, LEFTYB, left-right determination factor 1
External IDs	OMIM: 603037 MGI: 107405 HomoloGene: 49231 GeneCards: LEFTY1
Gene location (Human)
Chr.	Chromosome 1 (human)
End	225,911,382 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	180,765,965 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; rectum; ; endometrium; ; appendix; ; monocyte; ; cerebellar hemisphere; ; nucleus accumbens; ; Brodmann area 9; ; prefrontal cortex; ; putamen;
	Top expressed in
	neural plate; ; Region I of hippocampus proper; ; lip; ; ankle joint; ; islet of Langerhans; ; epithelium of stomach; ; Paneth cell; ; left colon; ; skin of abdomen; ; parotid gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	transforming growth factor beta receptor binding; cytokine activity; growth factor activity;
Cellular component	extracellular region; extracellular space;
Biological process	regulation of apoptotic process; multicellular organism development; positive regulation of pathway-restricted SMAD protein phosphorylation; heart morphogenesis; determination of left/right symmetry; negative regulation of transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; regulation of MAPK cascade; SMAD protein signal transduction; cell development; BMP signaling pathway; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	10637
	13590
	ENSG00000243709
	ENSMUSG00000038793
	O75610
	Q64280
	NM_020997
	NM_010094
	NP_066277
	NP_034224
	Wikidata
View/Edit Human	View/Edit Mouse

Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene.

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