Jun dimerization protein

JDP2
Identifiers
Aliases	JDP2, JUNDM2, Jun dimerization protein 2
External IDs	OMIM: 608657 MGI: 1932093 HomoloGene: 12787 GeneCards: JDP2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,474,111 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,686,652 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; synovial membrane; ; Achilles tendon; ; vena cava; ; sural nerve; ; lower lobe of lung; ; right lung; ; saphenous vein; ; monocyte; ; spleen;
	Top expressed in
	conjunctival fornix; ; calvaria; ; body of femur; ; cervix; ; cornea; ; fossa; ; right lung lobe; ; membranous bone; ; substantia nigra; ; belly cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; double-stranded DNA binding; chromatin binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription corepressor activity;
Cellular component	nucleus;
Biological process	positive regulation of histone deacetylation; regulation of transcription by RNA polymerase II; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; regulation of histone deacetylation; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	122953
	81703
	ENSG00000140044
	ENSMUSG00000034271
	Q8WYK2
	P97875
	NM_001135047; NM_001135048; NM_001135049; NM_130469
	NM_001205052; NM_001205053; NM_030887; NM_001401266
	NP_001128519; NP_001128520; NP_001128521; NP_569736
	NP_001191981; NP_001191982; NP_112149; NP_001388195
	Wikidata
View/Edit Human	View/Edit Mouse

Jun dimerization protein 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. The Jun dimerization protein is a member of the AP-1 family of transcription factors.

JDP 2 was found by a Sos-recruitment system, to dimerize with c-Jun to repress AP-1-mediated activation. It was later identified by the yeast-two hybrid system to bind to activating transcription factor 2 (ATF2) to repress ATF-mediated transcriptional activation. JDP2 regulates 12-O-tetradecanoylphorbol-13-acetate (TPA) response element (TRE)- and cAMP-responsive element (CRE)-dependent transcription.

The JDP2 gene is located on human chromosome 14q24.3 (46.4 kb, 75,427,715 bp to 75,474,111 bp) and mouse chromosome 12 (39 kb, 85,599,105 bp to 85,639,878 bp), which is located at about 250 kbp in the Fos-JDP2-BATF locus. Alternative splicing of JDP2 generates at least two isoforms. The protein JDP2 has 163 amino acids, belongs to the family of basic leucine zipper (bZIP), and shows high homology with the ATF3 bZIP domain. The bZIP domain includes the amino acids from position 72 to 135, the basic motif from position 74 to 96, and the leucine zipper from 100 to 128. The molecular weight of the canonical JDP2 is 18,704 Da. The histone-binding region is located from position 35 to 72 and the inhibition of the histone acetyltransferase (INHAT) region is from position 35 to 135, which is located before the DNA-binding domain.

JDP2 is expressed ubiquitously but is detected mainly in the cerebellum, brain, lung, and testis. A JDP2 single nucleotide polymorphism (SNP) was detected in Japanese, Korean, and Dutch cohorts, and is associated with an increased risk of intracranial aneurysms.

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