ATF3

ATF3
Identifiers
Aliases	ATF3, activating transcription factor 3
External IDs	OMIM: 603148 MGI: 109384 HomoloGene: 1265 GeneCards: ATF3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	212,620,777 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	190,950,236 bp
RNA expression pattern
	Top expressed in
	vena cava; ; gastric mucosa; ; gallbladder; ; saphenous vein; ; trachea; ; urethra; ; pericardium; ; left uterine tube; ; cardia; ; mucosa of urinary bladder;
	Top expressed in
	plantaris muscle; ; islet of Langerhans; ; intestinal villus; ; jejunum; ; sciatic nerve; ; endocardial cushion; ; left colon; ; atrioventricular valve; ; mucous cell of stomach; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transcription cis-regulatory region binding; protein homodimerization activity; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein heterodimerization activity; identical protein binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleolus; nucleoplasm; CHOP-ATF3 complex; nucleus;
Biological process	regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of cell population proliferation; skeletal muscle cell differentiation; regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance; gluconeogenesis; cellular response to amino acid starvation; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; positive regulation of TRAIL-activated apoptotic signaling pathway; transcription, DNA-templated; positive regulation of gene expression; PERK-mediated unfolded protein response; positive regulation of transcription by RNA polymerase II; negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; endoplasmic reticulum unfolded protein response; transcription by RNA polymerase II; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	467
	11910
	ENSG00000162772
	ENSMUSG00000026628
	P18847
	Q60765
NM_001030287; NM_001040619; NM_001206484; NM_001206485; NM_001206486;
	NM_001206488; NM_001674; NM_004024
	NM_007498
NP_001025458; NP_001035709; NP_001193413; NP_001193415; NP_001193417;
	NP_001665
	NP_031524
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-3 is a protein that, in humans, is encoded by the ATF3 gene.

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