JWH-210

JWH-210
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; Illegal in Sweden, I-N (Poland);
Identifiers
	IUPAC name 4-Ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone;
CAS Number	824959-81-1 (JWH-210); 824960-02-3 (JWH-182);
PubChem CID	45270396;
ChemSpider	24617616 ;
UNII	R18JYO04PY;
CompTox Dashboard (EPA)	DTXSID301010019 ;
ECHA InfoCard	100.233.380
Chemical and physical data
Formula	C26H27NO
Molar mass	369.508 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c4cccc2c4c(CC)ccc2C(=O)c(c3)c1ccccc1n3CCCCC;
	InChI InChI=1S/C26H27NO/c1-3-5-10-17-27-18-24(22-13-8-9-14-25(22)27)26(28)23-16-15-19(4-2)20-11-6-7-12-21(20)23/h6-9,11-16,18H,3-5,10,17H2,1-2H3 ; Key:LACIUQLUNACUKC-UHFFFAOYSA-N ;
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JWH-210 is an analgesic chemical from the naphthoylindole family, which acts as a potent cannabinoid agonist at both the CB₁ and CB₂ receptors, with K_i values of 0.46 nM at CB₁ and 0.69 nM at CB₂. It is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series, having a higher binding affinity (i.e. lower K_i) at CB₁ than both its 4-methyl and 4-n-propyl homologues JWH-122 (CB₁ K_i 0.69 nM) and JWH-182 (CB₁ K_i 0.65 nM) respectively, and than the 4-methoxy compound JWH-081 (CB₁ K_i 1.2 nM). It was discovered by and named after John W. Huffman.

JWH-210 may be neurotoxic to animals when administered in high doses.

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