JWH-081

JWH-081
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics); CA: Schedule II; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; US: Schedule I; I-N (Poland);
Identifiers
	IUPAC name 4-Methoxynaphthalen-1-yl-(1-pentylindol-3-yl)methanone;
CAS Number	210179-46-7 ;
PubChem CID	10547208;
ChemSpider	8722599;
UNII	77E58024IT;
CompTox Dashboard (EPA)	DTXSID80175225 ;
ECHA InfoCard	100.230.181
Chemical and physical data
Formula	C25H25NO2
Molar mass	371.480 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCn3c1ccccc1c(c3)C(=O)c4c2ccccc2c(OC)cc4;
	InChI InChI=1S/C25H25NO2/c1-3-4-9-16-26-17-22(19-11-7-8-13-23(19)26)25(27)21-14-15-24(28-2)20-12-6-5-10-18(20)21/h5-8,10-15,17H,3-4,9,16H2,1-2H3; Key:UBMPKJKGUQDHRM-UHFFFAOYSA-N;
	(verify)

JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB₁ and CB₂ receptors. With a K_i of 1.2nM it is fairly selective for the CB₁ subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB₂(12.4nM). It was discovered by and named after John W. Huffman.

JWH-081 may be neurotoxic to animals when administered in high doses.

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