Interleukin 26

IL26
Identifiers
Aliases	IL26, AK155, IL-26, interleukin 26
External IDs	OMIM: 605679 HomoloGene: 81862 GeneCards: IL26
Gene location (Human)
Chr.	Chromosome 12 (human)
End	68,225,810 bp
RNA expression pattern
	Top expressed in
	appendix; ; amniotic fluid; ; lymph node; ; thymus; ; rectum; ; gallbladder; ; spleen; ; urinary bladder; ; blood; ; sigmoid colon;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity;
Cellular component	cytosol; extracellular space; extracellular region;
Biological process	cell-cell signaling; positive regulation of protein kinase B signaling; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of transcription by RNA polymerase II; positive regulation of stress-activated MAPK cascade; positive regulation of ERK1 and ERK2 cascade; negative regulation of epithelial cell proliferation; regulation of signaling receptor activity; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	55801
	n/a
	ENSG00000111536
	n/a
	Q9NPH9
	n/a
	NM_018402
	n/a
	NP_060872
	n/a
	Wikidata
View/Edit Human

Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene.

IL-26 is the most recently identified member of the IL-20 cytokine subfamily, which was formed according to the usage of common receptor subunits and similarities in target-cell profiles and functions. All cytokines belonging to this subfamily are members of the larger IL-10 family. IL-26 is expressed in certain herpesvirus-transformed T cells but not in primary stimulated T cells. IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2. By signaling through this receptor complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.