STAT1

STAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WWT, 1BF5, 1YVL, 2KA6
Identifiers
Aliases	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
External IDs	OMIM: 600555 MGI: 103063 HomoloGene: 21428 GeneCards: STAT1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	191,020,960 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,201,024 bp
RNA expression pattern
	Top expressed in
	appendix; ; monocyte; ; endothelial cell; ; lymph node; ; glomerulus; ; metanephric glomerulus; ; germinal epithelium; ; trigeminal ganglion; ; gallbladder; ; palpebral conjunctiva;
	Top expressed in
	thymus; ; spleen; ; submandibular gland; ; blood; ; subcutaneous adipose tissue; ; mucous cell of stomach; ; brown adipose tissue; ; white adipose tissue; ; right lung; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; RNA polymerase II general transcription initiation factor activity; signal transducer activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; identical protein binding; enzyme binding; tumor necrosis factor receptor binding; double-stranded DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; cadherin binding; histone acetyltransferase binding; histone binding; ubiquitin-like protein ligase binding; promoter-specific chromatin binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; CCR5 chemokine receptor binding; protein phosphatase 2A binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleolus; perinuclear region of cytoplasm; nucleus; cytosol; axon; dendrite; protein-containing complex;
Biological process	regulation of apoptotic process; metanephric mesenchymal cell proliferation involved in metanephros development; regulation of transcription, DNA-templated; cellular response to interferon-beta; regulation of transcription by RNA polymerase II; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; metanephric mesenchymal cell differentiation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription by RNA polymerase II; renal tubule development; response to interferon-beta; negative regulation of I-kappaB kinase/NF-kappaB signaling; transcription, DNA-templated; negative regulation of endothelial cell proliferation; regulation of type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; positive regulation of mesenchymal cell proliferation; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of angiogenesis; negative regulation by virus of viral protein levels in host cell; viral process; endothelial cell migration; positive regulation of transcription by RNA polymerase II; signal transduction; macrophage derived foam cell differentiation; positive regulation of erythrocyte differentiation; type I interferon signaling pathway; cellular response to interferon-gamma; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of transcription, DNA-templated; defense response to virus; interferon-gamma-mediated signaling pathway; receptor signaling pathway via JAK-STAT; response to nutrient; blood circulation; positive regulation of cell population proliferation; response to mechanical stimulus; response to organic cyclic compound; cellular response to insulin stimulus; response to cytokine; response to hydrogen peroxide; response to peptide hormone; positive regulation of smooth muscle cell proliferation; response to cAMP; positive regulation of nitric-oxide synthase biosynthetic process; cellular response to cytokine stimulus; cellular response to organic cyclic compound; positive regulation of transcription of Notch receptor target; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-9-mediated signaling pathway; defense response; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	6772
	20846
	ENSG00000115415
	ENSMUSG00000026104
	P42224
	P42225
	NM_007315; NM_139266
	NM_001205313; NM_001205314; NM_009283; NM_001357627
	NP_009330; NP_644671
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.

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