Endothelin 2

EDN2
Identifiers
Aliases	EDN2, ET2, PPET2, ET-2, endothelin 2
External IDs	OMIM: 131241 MGI: 95284 HomoloGene: 1477 GeneCards: EDN2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	41,484,683 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	120,024,557 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; vagina; ; right uterine tube; ; minor salivary gland; ; trachea; ; duodenum; ; rectum; ; body of pancreas; ; prostate; ; gallbladder;
	Top expressed in
	jejunum; ; ileum; ; duodenum; ; lip; ; left colon; ; intestinal villus; ; morula; ; facial motor nucleus; ; crypt of lieberkuhn of small intestine; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity; endothelin B receptor binding;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	positive regulation of prostaglandin-endoperoxide synthase activity; hormonal regulation of the force of heart contraction; regulation of systemic arterial blood pressure by endothelin; vasoconstriction; cytokine-mediated signaling pathway; positive regulation of cytosolic calcium ion concentration; neutrophil chemotaxis; positive regulation of heart rate; positive regulation of leukocyte chemotaxis; cell surface receptor signaling pathway; vein smooth muscle contraction; macrophage chemotaxis; regulation of vasoconstriction; positive regulation of cell population proliferation; artery smooth muscle contraction; energy homeostasis; macrophage activation; prostaglandin biosynthetic process; lung alveolus development; temperature homeostasis; positive regulation of the force of heart contraction by chemical signal; inositol phosphate-mediated signaling; positive regulation of smooth muscle contraction; calcium-mediated signaling; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1907
	13615
	ENSG00000127129
	ENSMUSG00000028635
	P20800
	P22389
	NM_001956; NM_001302269
	NM_007902
	NP_001289198; NP_001947
	NP_031928
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin 2 (ET-2) is a protein encoded by the EDN2 gene in humans. It was first discovered in 1988 by Yanagisawa and team and belongs to a family of three endothelin peptide isoforms (ET-1, ET-2, ET-3), which constrict blood vessels. ET-2 is encoded by genes on separate chromosomes to its isoforms and is mainly produced in vascular endothelial cells of the kidney, placenta, uterus, heart, central nervous system and intestine. It becomes present in the blood of animals and humans at levels ranging from 0.3pg/ml to 3pg/ml. ET-2 acts by binding to two different G-protein coupled receptors (GPCRs), the endothelin A receptor (EDNRA) and the endothelin B receptor (EDNRB).

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