Endothelin receptor type B

EDNRB
Identifiers
Aliases	EDNRB, ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A, ETB1, endothelin receptor type B
External IDs	OMIM: 131244 MGI: 102720 HomoloGene: 89 GeneCards: EDNRB
Gene location (Human)
Chr.	Chromosome 13 (human)
End	77,975,529 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	104,081,838 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; external globus pallidus; ; lower lobe of lung; ; superior vestibular nucleus; ; spinal ganglia; ; internal globus pallidus; ; right lung; ; placenta; ; pericardium; ; trigeminal ganglion;
	Top expressed in
	iris; ; pineal gland; ; globus pallidus; ; atrium; ; left lung lobe; ; ciliary body; ; paraventricular nucleus of hypothalamus; ; external carotid artery; ; cerebellar vermis; ; lateral hypothalamus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	endothelin receptor activity; G protein-coupled receptor activity; signal transducer activity; peptide hormone binding; protein binding; type 1 angiotensin receptor binding;
Cellular component	integral component of membrane; nuclear membrane; membrane; integral component of plasma membrane; membrane raft; plasma membrane;
Biological process	enteric smooth muscle cell differentiation; negative regulation of adenylate cyclase activity; positive regulation of protein phosphorylation; peripheral nervous system development; positive regulation of renal sodium excretion; response to organic cyclic compound; regulation of sensory perception of pain; positive regulation of urine volume; vasoconstriction; positive regulation of cytosolic calcium ion concentration; epithelial fluid transport; human ageing; vasodilation; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; cGMP-mediated signaling; regulation of fever generation; nervous system development; regulation of blood pressure; phospholipase C-activating G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; enteric nervous system development; vein smooth muscle contraction; response to lipopolysaccharide; macrophage chemotaxis; response to pain; neural crest cell migration; positive regulation of cell population proliferation; posterior midgut development; developmental pigmentation; pigmentation; sensory perception of pain; negative regulation of neuron maturation; positive regulation of penile erection; regulation of epithelial cell proliferation; melanocyte differentiation; cellular response to lipopolysaccharide; regulation of pH; signal transduction; endothelin receptor signaling pathway; calcium-mediated signaling; G protein-coupled receptor signaling pathway; response to endothelin;
	Sources:Amigo / QuickGO
Orthologs
	1910
	13618
	ENSG00000136160
	ENSMUSG00000022122
	P24530
	P48302
	NM_000115; NM_001122659; NM_001201397; NM_003991
	NM_001136061; NM_001276296; NM_007904
	NP_000106; NP_001116131; NP_001188326; NP_003982
	NP_001129533; NP_001263225; NP_031930
	Wikidata
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Endothelin receptor type B, (ET-B) is a protein that in humans is encoded by the EDNRB gene.

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