CXCR3

CXCR3
Identifiers
Aliases	CXCR3, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C motif chemokine receptor 3, CD182
External IDs	OMIM: 300574 MGI: 1277207 HomoloGene: 1153 GeneCards: CXCR3
Gene location (Human)
Chr.	X chromosome (human)
End	71,618,511 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,777,875 bp
RNA expression pattern
	Top expressed in
	lymph node; ; blood; ; spleen; ; appendix; ; bone marrow; ; duodenum; ; gallbladder; ; face; ; pharynx; ; thymus;
	Top expressed in
	secondary oocyte; ; submandibular gland; ; blood; ; spleen; ; right ventricle; ; subcutaneous adipose tissue; ; thymus; ; white adipose tissue; ; upper arm; ; triceps brachii muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; G protein-coupled receptor activity; C-X-C chemokine binding; signal transducer activity; chemokine binding; chemokine receptor activity; protein binding; signaling receptor activity; C-C chemokine receptor activity; C-C chemokine binding;
Cellular component	cytoplasm; integral component of membrane; membrane; integral component of plasma membrane; cell surface; external side of plasma membrane; plasma membrane; intracellular anatomical structure;
Biological process	negative regulation of execution phase of apoptosis; positive regulation of execution phase of apoptosis; positive regulation of cytosolic calcium ion concentration; T cell chemotaxis; chemokine-mediated signaling pathway; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP-mediated signaling; regulation of leukocyte migration; positive regulation of angiogenesis; negative regulation of endothelial cell proliferation; cell surface receptor signaling pathway; cell adhesion; positive regulation of chemotaxis; angiogenesis; positive regulation of cell population proliferation; chemokine (C-C motif) ligand 11 production; negative regulation of angiogenesis; inflammatory response; calcium-mediated signaling; positive regulation of transcription by RNA polymerase II; signal transduction; apoptotic process; chemotaxis; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; immune response; cell chemotaxis; regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	2833
	12766
	ENSG00000186810
	ENSMUSG00000050232
	P49682
	O88410
	NM_001142797; NM_001504
	NM_009910
	NP_001136269; NP_001495
	NP_034040
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine receptor CXCR3 is a Gα_i protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt). CXCR3-A binds to the CXC chemokines CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) whereas CXCR3-B can also bind to CXCL4 in addition to CXCL9, CXCL10, and CXCL11.

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