CXCL11

CXCL11
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1RJT
Identifiers
Aliases	CXCL11, H174, I-TAC, IP-9, IP9, SCYB11, SCYB9B, b-R1, C-X-C motif chemokine ligand 11
External IDs	OMIM: 604852 HomoloGene: 3944 GeneCards: CXCL11
Gene location (Human)
Chr.	Chromosome 4 (human)
End	76,041,415 bp
RNA expression pattern
	Top expressed in
	appendix; ; body of pancreas; ; lymph node; ; rectum; ; smooth muscle tissue; ; islet of Langerhans; ; monocyte; ; Achilles tendon; ; palpebral conjunctiva; ; spleen;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chemokine activity; cytokine activity; heparin binding; protein binding; CXCR3 chemokine receptor binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	chemotaxis; positive regulation of leukocyte chemotaxis; T cell chemotaxis; chemokine-mediated signaling pathway; response to lipopolysaccharide; cell-cell signaling; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP-mediated signaling; regulation of cell population proliferation; immune response; signal transduction; defense response; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; neutrophil chemotaxis; leukocyte chemotaxis; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	6373
	n/a
	ENSG00000169248
	n/a
	O14625
	n/a
	NM_005409; NM_001302123
	n/a
	NP_001289052; NP_005400
	n/a
	Wikidata
View/Edit Human

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene.

C-X-C motif chemokine 11 is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

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