Platelet factor 4

PF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RHP, 1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 4R9W, 4R9Y, 4RAU
Identifiers
Aliases	PF4, CXCL4, PF-4, SCYB4, platelet factor 4
External IDs	OMIM: 173460 MGI: 1888711 HomoloGene: 87791 GeneCards: PF4
Gene location (Human)
Chr.	Chromosome 4 (human)
End	73,982,027 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	90,921,242 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spongy bone; ; blood; ; bone marrow; ; bone marrow cells; ; periodontal fiber; ; spleen; ; biceps brachii; ; right lung; ; upper lobe of left lung;
	Top expressed in
	blood; ; sciatic nerve; ; dermis; ; ankle; ; carotid body; ; spleen; ; belly cord; ; abdominal wall; ; body of femur; ; right ventricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; heparin binding; CXCR3 chemokine receptor binding; chemokine activity; protein binding;
Cellular component	extracellular region; platelet alpha granule lumen; extracellular space; cytoplasm; collagen-containing extracellular matrix;
Biological process	cytokine-mediated signaling pathway; chemokine-mediated signaling pathway; positive regulation of macrophage differentiation; platelet degranulation; negative regulation of megakaryocyte differentiation; positive regulation of cAMP-mediated signaling; negative regulation of MHC class II biosynthetic process; leukocyte chemotaxis; chemotaxis; response to lipopolysaccharide; positive regulation of macrophage derived foam cell differentiation; positive regulation of gene expression; regulation of cell population proliferation; immune response; positive regulation of tumor necrosis factor production; negative regulation of angiogenesis; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; inflammatory response; positive regulation of transcription by RNA polymerase II; negative regulation of cytolysis; platelet activation; defense response; positive regulation of neutrophil chemotaxis; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of megakaryocyte differentiation; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; neutrophil chemotaxis; cellular response to lipopolysaccharide;
	Sources:Amigo / QuickGO
Orthologs
	5196
	56744
	ENSG00000163737
	ENSMUSG00000029373
	P02776
	Q9Z126
	NM_002619; NM_001363352
	NM_019932
	NP_002610; NP_001350281
	NP_064316
	Wikidata
View/Edit Human	View/Edit Mouse

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin-like molecules. Due to these roles, it is predicted to play a role in wound repair and inflammation. It is usually found in a complex with proteoglycan.

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