CD48

CD48
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EDO
Identifiers
Aliases	CD48, BCM1, BLAST, BLAST1, MEM-102, SLAMF2, hmCD48 molecule
External IDs	OMIM: 109530 MGI: 88339 HomoloGene: 1347 GeneCards: CD48
Gene location (Human)
Chr.	Chromosome 1 (human)
End	160,711,831 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	171,532,826 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; bone marrow cells; ; appendix; ; spleen; ; lymph node; ; rectum; ; spongy bone; ; gallbladder; ; periodontal fiber;
	Top expressed in
	spleen; ; blood; ; thymus; ; calvaria; ; subcutaneous adipose tissue; ; white adipose tissue; ; pharynx; ; right lung lobe; ; ankle joint; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; antigen binding; signaling receptor activity;
Cellular component	membrane raft; anchored component of membrane; plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; intrinsic component of plasma membrane;
Biological process	defense response; leukocyte migration; regulation of adaptive immune response;
	Sources:Amigo / QuickGO
Orthologs
	962
	12506
	ENSG00000117091
	ENSMUSG00000015355
	P09326
	P18181
	NM_001256030; NM_001778
	NM_007649; NM_001360767
	NP_001242959; NP_001769
	NP_031675; NP_001347696
	Wikidata
View/Edit Human	View/Edit Mouse

CD48 antigen (Cluster of Differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.

CD48 is a member of the CD2 subfamily of the immunoglobulin superfamily (IgSF) which includes SLAM (signaling lymphocyte activation molecules) proteins, such as CD84, CD150, CD229 and CD244. CD48 is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells.

CD48 was the first B-cell-specific cellular differentiation antigen identified in transformed B lymphoblasts.

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