Signaling lymphocytic activation molecule
Signaling lymphocytic activation molecule (SLAM) is a family of genes. Homophilic binding between SLAMs is involved in cell-to-cell adhesion during antigen presentation.
| Signaling lymphocytic activation molecule | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | SLAM | ||||||||
| Pfam | PF06214 | ||||||||
| InterPro | IPR010407 | ||||||||
| Membranome | 164 | ||||||||
| |||||||||
Signaling lymphocytic activation molecules are a CD2-related surface receptor expressed by activated phagocytes, T helper cells, and platelets. SLAMs have a variety of functions, including enhancing T cellular proliferation by stimulating IL-4 and IFN-gamma production. SLAM family (SLAMF) receptors can interact directly with microbes, which can cause phagocytic cells to migrate to the area. SLAMF activation can trigger SLAM-associated protein (SAP) activation and a defective SAP can cause X-linked lymphoproliferative syndrome (XLP).
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