CD47

CD47
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JJS, 2JJT, 2VSC, 4CMM, 4KJY, 5IWL
Identifiers
Aliases	CD47, IAP, MER6, OA3, CD47 molecule
External IDs	OMIM: 601028 MGI: 96617 HomoloGene: 1346 GeneCards: CD47
Gene location (Human)
Chr.	Chromosome 3 (human)
End	108,091,862 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	49,735,373 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; germinal epithelium; ; visceral pleura; ; right uterine tube; ; pancreatic epithelial cell; ; Brodmann area 23; ; tibia; ; pancreatic ductal cell; ; postcentral gyrus; ; pons;
	Top expressed in
	blood; ; medial dorsal nucleus; ; cingulate gyrus; ; lateral geniculate nucleus; ; sciatic nerve; ; cerebellar vermis; ; spleen; ; right lung; ; ciliary body; ; left lung;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	thrombospondin receptor activity; protein binding; protein binding involved in heterotypic cell-cell adhesion; cell-cell adhesion mediator activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; specific granule membrane; tertiary granule membrane; extracellular exosome; cell surface;
Biological process	integrin-mediated signaling pathway; positive regulation of phagocytosis; cell adhesion; extracellular matrix organization; positive regulation of inflammatory response; positive regulation of T cell activation; response to bacterium; leukocyte migration; positive regulation of cell population proliferation; opsonization; positive regulation of cell-cell adhesion; neutrophil degranulation; cell migration; regulation of interferon-gamma production; regulation of interleukin-10 production; regulation of interleukin-12 production; regulation of interleukin-6 production; regulation of tumor necrosis factor production; heterotypic cell-cell adhesion; monocyte extravasation; regulation of nitric oxide biosynthetic process; positive regulation of stress fiber assembly; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to interleukin-12; cell-cell adhesion; negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	961
	16423
	ENSG00000196776
	ENSMUSG00000055447
	Q08722
	Q61735
	NM_001025079; NM_001025080; NM_001777; NM_198793; NM_001382306
	NM_010581; NM_001368415; NM_001368416; NM_001368417; NM_001368418
	NP_001768; NP_942088; NP_001369235
	NP_034711; NP_001355344; NP_001355345; NP_001355346; NP_001355347
	Wikidata
View/Edit Human	View/Edit Mouse

CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis.

CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in insulin secretion (DOI: 10.1126/scitranslmed.add2387), as well as immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.

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