Thrombospondin 1

THBS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LSL, 1UX6, 1Z78, 1ZA4, 2ERF, 2ES3, 2OUH, 2OUJ, 3R6B, 5FOE
Identifiers
Aliases	THBS1, THBS, THBS-1, TSP, TSP-1, TSP1, thrombospondin 1
External IDs	OMIM: 188060 MGI: 98737 HomoloGene: 31142 GeneCards: THBS1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	39,599,466 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	117,957,614 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastric mucosa; ; pericardium; ; gallbladder; ; left uterine tube; ; Achilles tendon; ; right lung; ; smooth muscle tissue; ; upper lobe of left lung; ; vena cava;
	Top expressed in
	calvaria; ; body of femur; ; retinal pigment epithelium; ; cumulus cell; ; belly cord; ; endocardial cushion; ; lower lip; ; right lung lobe; ; left lung lobe; ; blood;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; heparin binding; extracellular matrix binding; fibroblast growth factor binding; phosphatidylserine binding; proteoglycan binding; collagen V binding; fibrinogen binding; low-density lipoprotein particle binding; integrin binding; laminin binding; fibronectin binding; identical protein binding; transforming growth factor beta binding; protein binding; extracellular matrix structural constituent;
Cellular component	endoplasmic reticulum lumen; platelet alpha granule; cell surface; endoplasmic reticulum; extracellular exosome; extracellular matrix; secretory granule; platelet alpha granule lumen; fibrinogen complex; sarcoplasmic reticulum; external side of plasma membrane; cytoplasm; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	positive regulation of transforming growth factor beta receptor signaling pathway; cellular response to heat; negative regulation of fibrinolysis; protein O-linked fucosylation; response to progesterone; response to magnesium ion; positive regulation of translation; negative regulation of endothelial cell migration; negative regulation of cell-matrix adhesion; negative regulation of long-chain fatty acid import across plasma membrane; positive regulation of reactive oxygen species metabolic process; positive regulation of blood coagulation; positive regulation of blood vessel endothelial cell migration; positive regulation of macrophage chemotaxis; positive regulation of protein kinase B signaling; negative regulation of plasminogen activation; negative regulation of blood vessel endothelial cell migration; negative regulation of extrinsic apoptotic signaling pathway; response to endoplasmic reticulum stress; positive regulation of endothelial cell apoptotic process; response to unfolded protein; positive regulation of chemotaxis; negative regulation of cGMP-mediated signaling; positive regulation of phosphorylation; inflammatory response; negative regulation of focal adhesion assembly; chronic inflammatory response; negative regulation of nitric oxide mediated signal transduction; engulfment of apoptotic cell; extracellular matrix organization; positive regulation of macrophage activation; sprouting angiogenesis; negative regulation of apoptotic process; response to glucose; positive regulation of angiogenesis; response to calcium ion; positive regulation of transforming growth factor beta1 production; cell adhesion; behavioral response to pain; immune response; negative regulation of interleukin-12 production; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to hypoxia; positive regulation of cell migration; platelet degranulation; negative regulation of endothelial cell chemotaxis; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; negative regulation of fibroblast growth factor receptor signaling pathway; peptide cross-linking; negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; negative regulation of dendritic cell antigen processing and presentation; negative regulation of angiogenesis; cell migration; positive regulation of fibroblast migration; response to testosterone; cellular response to tumor necrosis factor; cellular response to growth factor stimulus; positive regulation of transforming growth factor beta production; response to mechanical stimulus; positive regulation of cell population proliferation; positive regulation of smooth muscle cell proliferation; regulation of megakaryocyte differentiation; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of sprouting angiogenesis;
	Sources:Amigo / QuickGO
Orthologs
	7057
	21825
	ENSG00000137801
	ENSMUSG00000040152
	P07996
	P35441
	NM_003246
	NM_011580; NM_001313914
	NP_003237
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Thrombospondin 1, abbreviated as THBS1, is a protein that in humans is encoded by the THBS1 gene.

Thrombospondin 1 is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.

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