Signal-regulatory protein alpha

SIRPA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JJS, 2JJT, 2UV3, 2WNG, 4CMM
Identifiers
Aliases	SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, Signal-regulatory protein alpha, signal regulatory protein alpha
External IDs	OMIM: 602461 MGI: 108563 HomoloGene: 7246 GeneCards: SIRPA
Gene location (Human)
Chr.	Chromosome 20 (human)
End	1,940,592 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	129,474,148 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; postcentral gyrus; ; prefrontal cortex; ; superior frontal gyrus; ; amygdala; ; middle temporal gyrus; ; nucleus accumbens; ; caudate nucleus; ; external globus pallidus; ; monocyte;
	Top expressed in
	prefrontal cortex; ; superior frontal gyrus; ; cerebellar cortex; ; entorhinal cortex; ; nucleus accumbens; ; primary motor cortex; ; hippocampus proper; ; amygdala; ; spleen; ; molar;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding; protein phosphatase binding; GTPase regulator activity; protein binding involved in heterotypic cell-cell adhesion; cell-cell adhesion mediator activity; protein antigen binding; protein tyrosine kinase binding;
Cellular component	integral component of membrane; plasma membrane; extracellular exosome; membrane; tertiary granule membrane; ficolin-1-rich granule membrane; integral component of plasma membrane; cell surface;
Biological process	cell adhesion; leukocyte migration; neutrophil degranulation; negative regulation of protein phosphorylation; regulation of gene expression; cell migration; positive regulation of cell-cell adhesion; regulation of interferon-gamma production; regulation of interleukin-1 beta production; regulation of interleukin-6 production; regulation of tumor necrosis factor production; negative regulation of interferon-beta production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor production; heterotypic cell-cell adhesion; monocyte extravasation; negative regulation of nitric oxide biosynthetic process; regulation of nitric oxide biosynthetic process; negative regulation of JNK cascade; negative regulation of inflammatory response; negative regulation of phagocytosis; positive regulation of phagocytosis; regulation of catalytic activity; positive regulation of T cell activation; cellular response to hydrogen peroxide; negative regulation of ERK1 and ERK2 cascade; cellular response to lipopolysaccharide; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to interleukin-12; negative regulation of macrophage inflammatory protein 1 alpha production; negative regulation of chemokine (C-C motif) ligand 5 production; cell-cell adhesion; negative regulation of cytokine production involved in inflammatory response; negative regulation of I-kappaB phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	140885
	19261
	ENSG00000198053
	ENSMUSG00000037902
	P78324
	P97797
	NM_001040022; NM_001040023; NM_080792; NM_001330728
NM_001177646; NM_001177647; NM_001291019; NM_001291020; NM_001291021;
	NM_001291022; NM_007547; NM_001355158; NM_001355160
	NP_001035111; NP_001035112; NP_001317657; NP_542970
NP_001171118; NP_001277948; NP_001277949; NP_001277950; NP_001277951;
	NP_031573; NP_001342087; NP_001342089
	Wikidata
View/Edit Human	View/Edit Mouse

Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.

SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don't eat me" signal. This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis. SIRPα diffuses laterally on the macrophage membrane and accumulates at a phagocytic synapse to bind CD47 and signal 'self', which inhibits the cytoskeleton-intensive process of phagocytosis by the macrophage. This is analogous to the self signals provided by MHC class I molecules to NK cells via Ig-like or Ly49 receptors. NB. Protein shown to the right is CD47 not SIRP α.

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