Complement component 3

Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a central role in the complement system of vertebrate animals and contributes to innate immunity. In humans it is encoded on chromosome 19 by a gene called C3.

C3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesC3, AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p, complement component 3, complement C3
External IDsOMIM: 120700 MGI: 88227 HomoloGene: 68031 GeneCards: C3
Orthologs
SpeciesHumanMouse
Entrez

718

12266

Ensembl

ENSG00000125730

ENSMUSG00000024164

UniProt

P01024

P01027

RefSeq (mRNA)

NM_000064

NM_009778

RefSeq (protein)

NP_000055

NP_033908

Location (UCSC)Chr 19: 6.68 – 6.73 MbChr 17: 57.51 – 57.54 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Deficiencies and defects of C3 result in the affected person being immunocompromised and particularly vulnerable to bacterial infections.

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