Protein c-Fos

FOS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A02, 1FOS, 1S9K
Identifiers
Aliases	FOS, AP-1, C-p55, Fos proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 164810 MGI: 95574 HomoloGene: 3844 GeneCards: FOS
Gene location (Human)
Chr.	Chromosome 14 (human)
End	75,282,230 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	85,524,047 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; gallbladder; ; left uterine tube; ; monocyte; ; nipple; ; trachea; ; tibial nerve; ; skin of abdomen; ; seminal vesicula; ; cardia;
	Top expressed in
	dermis; ; belly cord; ; pyloric antrum; ; left colon; ; cumulus cell; ; mucous cell of stomach; ; intestinal villus; ; duodenum; ; jejunum; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; R-SMAD binding; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; transcription factor binding; chromatin binding; protein binding; protein heterodimerization activity; double-stranded DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; cytosol; membrane; transcription regulator complex; nucleoplasm; endoplasmic reticulum; neuron projection; nucleus; protein-DNA complex; transcription factor AP-1 complex;
Biological process	cellular response to extracellular stimulus; response to muscle stretch; response to immobilization stress; cellular response to calcium ion; response to cytokine; regulation of transcription, DNA-templated; SMAD protein signal transduction; response to organic cyclic compound; response to light stimulus; regulation of transcription by RNA polymerase II; response to progesterone; female pregnancy; response to corticosterone; response to mechanical stimulus; human ageing; positive regulation of osteoclast differentiation; transcription by RNA polymerase II; nervous system development; cellular response to reactive oxygen species; response to gravity; Fc-epsilon receptor signaling pathway; positive regulation of transcription, DNA-templated; DNA methylation; response to lipopolysaccharide; sleep; cellular response to hormone stimulus; regulation of DNA-binding transcription factor activity; conditioned taste aversion; skeletal muscle cell differentiation; response to cold; response to cAMP; inflammatory response; transforming growth factor beta receptor signaling pathway; positive regulation of pri-miRNA transcription by RNA polymerase II; response to toxic substance; positive regulation of transcription by RNA polymerase II; regulation of gene expression; cytokine-mediated signaling pathway; cellular response to cadmium ion; positive regulation of neuron death;
	Sources:Amigo / QuickGO
Orthologs
	2353
	14281
	ENSG00000170345
	ENSMUSG00000021250
	P01100; Q6FG41
	P01101
	NM_005252
	NM_010234
	NP_005243; NP_005243.1
	NP_034364
	Wikidata
View/Edit Human	View/Edit Mouse

Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982). It is a part of a bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.

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