Transcription factor Jun

JUN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
Identifiers
Aliases	JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit, p39, cJUN
External IDs	OMIM: 165160 MGI: 96646 HomoloGene: 1679 GeneCards: JUN
Gene location (Human)
Chr.	Chromosome 1 (human)
End	58,784,048 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	94,940,459 bp
RNA expression pattern
	Top expressed in
	vena cava; ; gastric mucosa; ; cardia; ; lactiferous duct; ; saphenous vein; ; seminal vesicula; ; pericardium; ; parotid gland; ; endothelial cell; ; pylorus;
	Top expressed in
	left lung lobe; ; dermis; ; right lung; ; right lung lobe; ; temporal muscle; ; aortic valve; ; digastric muscle; ; adrenal gland; ; ankle; ; supraoptic nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; DNA-binding transcription factor activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; cAMP response element binding; R-SMAD binding; HMG box domain binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; enzyme binding; chromatin binding; protein binding; double-stranded DNA binding; DNA binding; sequence-specific DNA binding; transcription coactivator activity; identical protein binding; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; RNA binding; protein homodimerization activity; protein heterodimerization activity; ubiquitin protein ligase binding; ubiquitin-like protein ligase binding; transcription cis-regulatory region binding;
Cellular component	cytosol; transcription repressor complex; nucleus; nuclear chromosome; nucleoplasm; transcription regulator complex; transcription factor AP-1 complex;
Biological process	negative regulation of neuron apoptotic process; negative regulation of DNA binding; outflow tract morphogenesis; transcription by RNA polymerase II; learning; monocyte differentiation; response to organic substance; leading edge cell differentiation; Fc-epsilon receptor signaling pathway; positive regulation of neuron apoptotic process; cellular response to hormone stimulus; regulation of DNA-binding transcription factor activity; circadian rhythm; angiogenesis; positive regulation of ERK1 and ERK2 cascade; Ras protein signal transduction; transforming growth factor beta receptor signaling pathway; negative regulation of cell population proliferation; response to muscle stretch; cellular response to calcium ion; response to cytokine; regulation of transcription, DNA-templated; SMAD protein signal transduction; axon regeneration; positive regulation of fibroblast proliferation; response to mechanical stimulus; positive regulation of epithelial cell migration; positive regulation of DNA-templated transcription, initiation; transcription, DNA-templated; positive regulation of cell differentiation; positive regulation of monocyte differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; negative regulation of protein autophosphorylation; membrane depolarization; negative regulation of apoptotic process; eyelid development in camera-type eye; microglial cell activation; positive regulation of DNA replication; response to lipopolysaccharide; response to radiation; response to cAMP; negative regulation of transcription, DNA-templated; response to hydrogen peroxide; positive regulation of smooth muscle cell proliferation; positive regulation of endothelial cell proliferation; response to organic cyclic compound; human ageing; regulation of cell cycle; regulation of cell population proliferation; positive regulation of cell population proliferation; liver development; negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; cellular response to potassium ion starvation; cellular process; release of cytochrome c from mitochondria; positive regulation of transcription by RNA polymerase II; positive regulation of GTPase activity; cellular response to reactive oxygen species; positive regulation of apoptotic process; positive regulation of transcription, DNA-templated; cellular response to cadmium ion; negative regulation of transcription by RNA polymerase II; positive regulation of vascular associated smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3725
	16476
	ENSG00000177606
	ENSMUSG00000052684
	P05412
	P05627
	NM_002228
	NM_010591
	NP_002219
	NP_034721
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. c-jun was the first oncogenic transcription factor discovered. The proto-oncogene c-Jun is the cellular homolog of the viral oncoprotein v-jun (P05411). The viral homolog v-jun was discovered in avian sarcoma virus 17 and was named for ju-nana, the Japanese word for 17. The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

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